ArticlePsychopharmacology2010
Gestational exposure to the organophosphate chlorpyrifos alters social-emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in mice.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models.International journal of environmental research and public health · 2021Pooled it
- Pesticide exposure and neurodevelopmental outcomes: review of the epidemiologic and animal studies.Journal of toxicology and environmental health. Part B, Critical reviews · 2013Pooled it
- Sex andToxics · 2026Article
- Chronic dimethomorph exposure induced behaviors abnormalities and cognitive performance alterations in adult zebrafish (Toxicology reports · 2025Article
- Organophosphorus pesticide exposure from house dust and parent-reported child behavior in Latino children from an orchard community.Neurotoxicology · 2024Article
- Exposure to Environmental Pesticides and the Risk of Autism Spectrum Disorders: A Population-Based Case-Control Study.Medicina (Kaunas, Lithuania) · 2024Article
- Chlorpyrifos Occurrence and Toxicological Risk Assessment: A Review.International journal of environmental research and public health · 2022Review
- Associations between pesticide mixtures applied near home during pregnancy and early childhood with adolescent behavioral and emotional problems in the CHAMACOS study.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Isolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism.Frontiers in neuroscience · 2021Article
- Translational outcomes relevant to neurodevelopmental disorders following early life exposure of rats to chlorpyrifos.Journal of neurodevelopmental disorders · 2020Article
- Inhibition of fatty acid amide hydrolase by chlorpyrifos in juvenile rats results in altered exploratory and social behavior as adolescents.Neurotoxicology · 2020Article
- Sex and Time-of-Day Impact on Anxiety and Passive Avoidance Memory Strategies in Mice.Frontiers in behavioral neuroscience · 2020Article
- Sex-Specific Neurotoxic Effects of Organophosphate Pesticides Across the Life Course.Current environmental health reports · 2017Review
- Prenatal exposure to organophosphorus pesticides and childhood neurodevelopmental phenotypes.Environmental research · 2017Article
- Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development.Neurotoxicology · 2017Article
- Developmental neurotoxicity of succeeding generations of insecticides.Environment international · 2017Review
- Prenatal exposure to the organophosphate insecticide chlorpyrifos enhances brain oxidative stress and prostaglandin E2 synthesis in a mouse model of idiopathic autism.Journal of neuroinflammation · 2016Article
- Chlorpyrifos and malathion have opposite effects on behaviors and brain size that are not correlated to changes in AChE activity.Neurotoxicology · 2015Article
- Effects of maternal chlorpyrifos diet on social investigation and brain neuroendocrine markers in the offspring - a mouse study.Environmental health : a global access science source · 2015Article
- Strain dependent effects of conditioned fear in adult C57Bl/6 and Balb/C mice following postnatal exposure to chlorpyrifos: relation to expression of brain acetylcholinesterase mRNA.Frontiers in behavioral neuroscience · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe organophosphate chlorpyrifos (CPF) is a pesticide largely used worldwide. Studies from animal models indicate that CPF exposure during development at low doses can target different neurotransmitter systems in the absence of overt cholinergic effects.
methodsLate gestational exposure (gestational days 14-17) to CPF at the dose of 6 mg/kg was evaluated in CD-1 mice at adulthood. Neurobehavioural effects likely involving serotonin (5-hydroxytryptamine, 5HT) transmission were assessed both in males and females, through the light-dark exploration test to assess CPF effects on anxiety profiles and the forced swimming test to evaluate the response to the 5HT transporter (5HTT) inhibitor fluvoxamine (30 mg/kg). In females only, we evaluated the effects of gestational exposure to CPF on maternal aggression, under basal condition or after injection of fluvoxamine.
resultsGestational CPF exposure increased anxiety levels only in female mice, as shown by the augmented thigmotaxis behaviour and the lower latency to enter in the dark compartment. In the forced swimming test, no differences between CPF and control mice were found when assessed under basal condition (saline administration), but both male and female CPF mice missed to show the typical behavioural effects of the 5HTT inhibitor fluvoxamine. During maternal aggression, CPF females showed lower propensity to and intensity of aggressive behaviour, together with mild decreased responsiveness to fluvoxamine administration.
conclusionsOverall, the present results confirm a specific and sex-dependent vulnerability of affective/emotional domains to developmental CPF exposure. Furthermore, data provide clear indication on the disrupting effects of prenatal CPF on serotoninergic transmission.
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