ArticleIntensive care medicine2010
PTX3 as a potential biomarker of acute lung injury: supporting evidence from animal experimentation.
Article in Intensive care medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Persisting high levels of plasma pentraxin 3 over the first days after severe sepsis and septic shock onset are associated with mortality.Intensive care medicine · 2010Trial
- Acute lung injury induced by recombinant SARS-CoV-2 spike protein subunit S1 in mice.Respiratory research · 2025Article
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- Empagliflozin Inhibits IL-1β-Mediated Inflammatory Response in Human Proximal Tubular Cells.International journal of molecular sciences · 2021Article
- Accumulation and phytotoxicity of perfluorooctanoic acid and 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate in Arabidopsis thaliana and Nicotiana benthamiana.Environmental pollution (Barking, Essex : 1987) · 2020Article
- Plasma PTX3, MCP1 and Ang2 are early biomarkers to evaluate the severity of sepsis and septic shock.Scandinavian journal of immunology · 2019Article
- Transcriptome-wide analysis of filarial extract-primed human monocytes reveal changes in LPS-induced PTX3 expression levels.Scientific reports · 2019Article
- Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model.Oncotarget · 2018Article
- XB130 deficiency enhances lipopolysaccharide-induced septic response and acute lung injury.Oncotarget · 2016Article
- Nogo-B protects mice against lipopolysaccharide-induced acute lung injury.Scientific reports · 2015Article
- Diagnostic and prognostic utility of tissue factor for severe sepsis and sepsis-induced acute lung injury.Journal of translational medicine · 2015Article
- Pentraxin 3 Plasma Levels and Disease Activity in Systemic Lupus Erythematosus.Autoimmune diseases · 2015Article
- Pleural fluid pentraxin-3 for the differential diagnosis of pleural effusions.Tuberculosis and respiratory diseases · 2013Article
- Biology of human pentraxin 3 (PTX3) in acute and chronic kidney disease.Journal of clinical immunology · 2013Review
- Synergistic effects of hypertonic saline and valproic acid in a lethal rat two-hit model.The journal of trauma and acute care surgery · 2013Article
- Pentraxin 3 as a new biomarker of peritoneal injury in peritoneal dialysis patients.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2013Article
- Variation in PTX3 is associated with primary graft dysfunction after lung transplantation.American journal of respiratory and critical care medicine · 2012Article
- Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice.Laboratory investigation; a journal of technical methods and pathology · 2012Article
- Src tyrosine kinase inhibition prevents pulmonary ischemia-reperfusion-induced acute lung injury.Intensive care medicine · 2012Article
- Cerebrospinal fluid pentraxin 3 early after subarachnoid hemorrhage is associated with vasospasm.Intensive care medicine · 2011Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveIncreased expression of long pentraxin 3 (PTX3) has been found in patients with sepsis or acute respiratory distress syndrome. Tissue factor (TF) activation plays an important role in the pathogenesis of acute lung injury. The present study sought to determine the relationship between PTX3 expression and TF activation in acute lung injury.
methodsLung injury was induced by intratracheal instillation of lipopolysaccharide (LPS) in mice, and the PTX3 expression, TF activation and lung injury were determined. We also treated the lung injury with an anti-human tissue factor monoclonal antibody in human tissue factor knock-in (hTF-KI) mice.
resultsBalb/c mice were challenged with increasing doses of LPS. After 24 h, PTX3 protein in the bronchioalveolar lavage fluid was increased in parallel with the severity of lung injury, and correlated with tissue factor (TF) activity. The expression and distribution of PTX3 and TF were further documented in detail 6 h after LPS (5 mg/kg) instillation. Treatment with anti-human TF monoclonal antibody dramatically attenuated LPS-induced lung injury, alveolar fibrin deposition and inflammatory cell infiltration in"humanized" hTF-KI mice 6 h after LPS challenge. The PTX3 expression was significantly decreased by the anti-coagulant therapy.
conclusionThese results support the clinical finding that PTX3 may be a useful biomarker to the reflect severity of lung injury and provide effective therapies. The interplay between PTX3 and TF could be a potential mechanism that mediates lung injury.
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