ArticlePatient preference and adherence2008
Adherence and persistence to typical and atypical antipsychotics in the naturalistic treatment of patients with schizophrenia.
Article in Patient preference and adherence, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Pooled it
- Antipsychotic Drugs and the Risk of Diabetic Complications: A Systematic Review of Observational Studies.Journal of clinical medicine · 2026Review
- Consumers' and practitioners' perspectives on the antipsychotic induced metabolic syndrome and challenges in metabolic monitoring to patient prescribed second generation antipsychotics in severe mental illness.Journal of health psychology · 2025Article
- The Impact of Drug Delivery Systems on Pharmacokinetics and Drug-Drug Interactions in Neuropsychiatric Treatment.Cureus · 2025Review
- Article
- Adherence to Typical Antipsychotics among Patients with Schizophrenia in Uganda: A Cross-Sectional Study.Schizophrenia research and treatment · 2023Article
- Treatment persistence in patients with schizophrenia treated with lurasidone in Italian clinical practice.Annals of general psychiatry · 2022Article
- Treatment persistence with aripiprazole once monthly: a 4-year follow-up.Annals of general psychiatry · 2022Article
- Switching Between Second-Generation Antipsychotics in Patients with Schizophrenia and Schizoaffective Disorder: 10-Year Cohort Study in Brazil.Frontiers in pharmacology · 2021Article
- Persistence of Antipsychotic Use After Clozapine Discontinuation: A Real-World Study Across Antipsychotics.Clinical and translational science · 2020Article
- Active Ingredients and Mechanisms of Change in Motivational Interviewing for Medication Adherence. A Mixed Methods Study of Patient-Therapist Interaction in Patients With Schizophrenia.Frontiers in psychiatry · 2020Article
- Factors Related to Early Clinical Effects of Quetiapine Extended-Release: A Multinational, Prospective, Observational Study.Clinical drug investigation · 2016Observational
- Persistence of Antipsychotic Treatment in Elderly Dementia Patients: A Retrospective, Population-Based Cohort Study.Drugs - real world outcomes · 2016Article
- Development of the My Medicines and Me (M3Q) side effect questionnaire for mental health patients: a qualitative study.Therapeutic advances in psychopharmacology · 2015Article
- Antipsychotic Adherence and Rehospitalization in Schizophrenia Patients Receiving Oral Versus Long-Acting Injectable Antipsychotics Following Hospital Discharge.Journal of managed care & specialty pharmacy · 2015Article
- Predictors of medication non-adherence in Bulgarian outpatients with schizophrenia.Community mental health journal · 2014Article
- Towards a framework for treatment effectiveness in schizophrenia.Neuropsychiatric disease and treatment · 2014Article
- Factors associated with early response to olanzapine and clinical and functional outcomes of early responders treated for schizophrenia in the People's Republic of China.Neuropsychiatric disease and treatment · 2014Article
- Adherence and Continuation of Treatment with First- and Second-generation Antipsychotics in Schizophrenia.Indian journal of psychological medicine · 2014Article
- Effectiveness of sulpiride in adult patients with schizophrenia.Schizophrenia bulletin · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare adherence and persistence to typical versus atypical antipsychotics and between specific atypical agents in the usual care of schizophrenia and to examine the association between adherence and persistence.
methodData were drawn from a 3-year prospective, nonrandomized, noninterventional study of schizophrenia conducted during 1997-2003. Initiators on haloperidol, risperidone, olanzapine, quetiapine, and clozapine with at least 1 year of follow-up were included (n = 878). Adherence (Medication Possession Ratio, MPR) and persistence (time to all-cause medication discontinuation) were assessed using medical record prescription information. Analyses employed multivariate statistics adjusted for group differences.
resultsOverall, 58% of the patients were deemed adherent (MPR >80%). Adherence rates were higher: for atypical (59.4%) than typical antipsychotics (34.5%, p < 0.001), for clozapine (77%) than each comparator excluding olanzapine (p < 0.01), and for olanzapine (64%) than risperidone (57%, p = 0.027) and quetiapine (52%, p = 0.019). Differences between risperidone and quetiapine were not statistically significant. Adherence and persistence were highly correlated (r = 0.957, p < 0.001).
conclusionIn the usual care of schizophrenia, medication adherence and persistence appear to be highly correlated and to significantly differ between typical and atypical antipsychotics and among atypical agents. The choice of antipsychotic may play a meaningful role in patients' adherence to and persistence with antipsychotic medications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.