ArticleProceedings of the National Academy of Sciences of the United States of America2009
Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Human CD4iScience · 2024Article
- Emerging strategies for treating autoimmune disease with genetically modified dendritic cells.Cell communication and signaling : CCS · 2024Review
- Excess generation and activation of naturally arising memory-phenotype CD4Frontiers in immunology · 2024Article
- Article
- Downregulation of MALAT1 is a hallmark of tissue and peripheral proliferative T cells in COVID-19.Clinical and experimental immunology · 2023Article
- Memory-phenotype CD4JMA journal · 2022Review
- Memory-phenotype CD4+ T cells: a naturally arising T lymphocyte population possessing innate immune function.International immunology · 2022Review
- Changes in T-cell subsets and clonal repertoire during chemoimmunotherapy with pembrolizumab and paclitaxel or capecitabine for metastatic triple-negative breast cancer.Journal for immunotherapy of cancer · 2022Article
- Homeostasis of Naive and Memory T Lymphocytes.Cold Spring Harbor perspectives in biology · 2021Review
- Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma.Cell research · 2020Article
- Requirements for the differentiation of innate T-betNature communications · 2020Article
- TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis.PLoS biology · 2019Article
- Interferon-γ Receptor Signaling in Dendritic Cells Restrains Spontaneous Proliferation of CD4Frontiers in immunology · 2019Article
- Spontaneous T Cell Proliferation: A Physiologic Process to Create and Maintain Homeostatic Balance and Diversity of the Immune System.Frontiers in immunology · 2018Review
- Spontaneous Proliferation of CD4Frontiers in immunology · 2018Article
- Getting in and Staying Alive: Role for Coronin 1 in the Survival of Pathogenic Mycobacteria and Naïve T Cells.Frontiers in immunology · 2018Review
- CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection.Frontiers in immunology · 2016Article
- Cutting edge: IFN-γR signaling in non-T cell targets regulates T cell-mediated intestinal inflammation through multiple mechanisms.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- CD4 T cell activation by B cells in human Leishmania (Viannia) infection.BMC infectious diseases · 2014Article
- Spontaneous proliferation of H2M-/- CD4 T cells results in unusual acute hepatocellular necrosis.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
T cells transferred into severe lymphopenic hosts undergo rapid proliferation known as "endogenous proliferation" that are distinct from conventional homeostatic proliferation. Unlike homeostatic proliferation, cytokines, such as IL-7 are dispensable, yet TCR:MHC interaction is essential for this process to occur. However, cell types inducing the proliferation have not formally been addressed. In this study, we report that CD11c+ conventional DCs play irreplaceable roles in inducing endogenous proliferation of both naive and memory phenotype CD4 T cells via TCR-MHC II interaction. By contrast, CD8 T-cell endogenous proliferation was independent of MHC I or CD11c+ DCs. Interestingly, MHC II was necessary to support naive CD8 T-cell proliferation within MHC I-deficient hosts. Depletion of both B cells and DCs was sufficient to abrogate the proliferation of naive but not of memory CD8 T cells. These results suggest that depending on the T-cell lineages, as well as the differentiation status, different mechanisms control endogenous proliferation, revealing in vivo complexity of T-cell proliferation under lymphopenic conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.