ArticleThe Journal of biological chemistry2010
The full-length unprocessed hedgehog protein is an active signaling molecule.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Article
- Hedgehog Autoprocessing: From Structural Mechanisms to Drug Discovery.Frontiers in molecular biosciences · 2022Review
- Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia.Communications biology · 2021Article
- Article
- DHH pathogenic variants involved in 46,XY disorders of sex development differentially impact protein self-cleavage and structural conformation.Human genetics · 2020Article
- Article
- Article
- Sonic hedgehog expression in the postnatal brain.Biology open · 2019Article
- Gain-of-function Shh mutants activate Smo cell-autonomously independent of Ptch1/2 function.Mechanisms of development · 2018Article
- Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life.Journal of developmental biology · 2018Review
- Loss-of-function mutations in FGF8 can be independent risk factors for holoprosencephaly.Human molecular genetics · 2018Article
- From top to bottom: Cell polarity in Hedgehog and Wnt trafficking.BMC biology · 2018Review
- Membrane-bound full-length Sonic Hedgehog identifies cancer stem cells in human non-small cell lung cancer.Oncotarget · 2017Article
- Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor Lesions.Cellular and molecular gastroenterology and hepatology · 2017Review
- Perspectives on Intra- and Intercellular Trafficking of Hedgehog for Tissue Patterning.Journal of developmental biology · 2016Review
- Hedgehog signaling in the stomach.Current opinion in pharmacology · 2016Review
- Review
- Identification of a family of fatty-acid-speciated sonic hedgehog proteins, whose members display differential biological properties.Cell reports · 2015Article
- A new role for Hedgehogs in juxtacrine signaling.Mechanisms of development · 2014Article
- Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer.Current opinion in pharmacology · 2012Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
The hedgehog (HH) family of ligands plays an important instructional role in metazoan development. HH proteins are initially produced as approximately 45-kDa full-length proteins, which undergo an intramolecular cleavage to generate an amino-terminal product that subsequently becomes cholesterol-modified (HH-Np). It is well accepted that this cholesterol-modified amino-terminal cleavage product is responsible for all HH-dependent signaling events. Contrary to this model we show here that full-length forms of HH proteins are able to traffic to the plasma membrane and participate directly in cell-cell signaling, both in vitro and in vivo. We were also able to rescue a Drosophila eye-specific hh loss of function phenotype by expressing a full-length form of hh that cannot be processed into HH-Np. These results suggest that in some physiological contexts full-length HH proteins may participate directly in HH signaling and that this novel activity of full-length HH may be evolutionarily conserved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.