ArticleCirculation. Cardiovascular imaging2009
Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.
Article in Circulation. Cardiovascular imaging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
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- Emerging methods for the characterization of ischemic heart disease: ultrafast Doppler angiography, micro-CT, photon-counting CT, novel MRI and PET techniques, and artificial intelligence.European radiology experimental · 2021Review
- Acute Cardiac Unloading and Recovery: Proceedings of the 4th Annual Acute Cardiac Unloading and REcovery (A-CURE) symposium held on 30 August 2019 in Paris, France.Interventional cardiology (London, England) · 2019Article
- Molecular Imaging of the Heart.Comprehensive Physiology · 2019Review
- Molecular Imaging in Ischemic Heart Disease.Current cardiovascular imaging reports · 2019Review
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- Cardiac magnetic resonance imaging of rapid VCAM-1 up-regulation in myocardial ischemia-reperfusion injury.European biophysics journal : EBJ · 2013Article
- A network-oriented perspective on cardiac calcium signaling.American journal of physiology. Cell physiology · 2012Review
- Potential of magnetic nanoparticles for targeted drug delivery.Nanotechnology, science and applications · 2012Review
- Synthesis of an in vivo MRI-detectable apoptosis probe.Journal of visualized experiments : JoVE · 2012Article
- Straightforward thiol-mediated protein labelling with DTPA: Synthesis of a highly active 111In-annexin A5-DTPA tracer.EJNMMI research · 2012Article
- Protective effect of the apoptosis-sensing nanoparticle AnxCLIO-Cy5.5.Nanomedicine : nanotechnology, biology, and medicine · 2012Article
- Prometheus's heart: what lies beneath.Journal of cellular and molecular medicine · 2012Article
- Epidemiological survey on the prevalence of periodontitis and diabetes mellitus in Uyghur adults from rural Hotan area in Xinjiang.Experimental diabetes research · 2012Article
- Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy.Accounts of chemical research · 2011Review
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12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe ability to image cardiomyocyte (CM) apoptosis in heart failure could facilitate more accurate diagnostics and optimize targeted therapeutics. We thus aimed to develop a platform to image CM apoptosis quantitatively and specifically in heart failure in vivo. The myocardium in heart failure, however, is characterized by very low levels of CM apoptosis and normal vascular permeability, factors thought to preclude the use of molecular MRI. METHODS AND
resultsFemale mice with overexpression of Gaq were studied. Two weeks postpartum, these mice develop a cardiomyopathy characterized by low levels of CM apoptosis and minimal myocardial necrosis or inflammation. The mice were injected with the annexin-labeled nanoparticle (AnxCLIO-Cy5.5) or a control probe (CLIO-Cy5.5) and imaged in vivo at 9.4 T. Uptake of AnxCLIO-Cy5.5 occurred in isolated clusters, frequently in the subendocardium. Myocardial T2* was significantly lower (7.6+/-1.5 versus 16.8+/-2.7 ms, P<0.05) in the mice injected with AnxCLIO-Cy5.5 versus CLIO-Cy5.5, consistent with the uptake of AnxCLIO-Cy5.5 by apoptotic CMs. A strong correlation (r(2)=0.86, P<0.05) was seen between in vivo T2* (AnxCLIO-Cy5.5 uptake) and myocardial caspase-3 activity.
conclusionsThe ability of molecular MRI to image sparsely expressed targets in the myocardium is demonstrated in this study. Moreover, a novel platform for high-resolution and specific imaging of CM apoptosis in heart failure is established. In addition to providing novel insights into the pathogenesis of CM apoptosis, the developed platform could facilitate the development of novel antiapoptotic therapies in heart failure.
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