ArticleCirculation. Cardiovascular imaging2010
Timing of bone marrow cell delivery has minimal effects on cell viability and cardiac recovery after myocardial infarction.
Article in Circulation. Cardiovascular imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Post-myocardial Infarction Cardiac Remodeling: Multidimensional Mechanisms and Clinical Prospects of Stem Cell Therapy.Stem cell reviews and reports · 2025Review
- Concise Review: Reduction of Adverse Cardiac Scarring Facilitates Pluripotent Stem Cell-Based Therapy for Myocardial Infarction.Stem cells (Dayton, Ohio) · 2019Review
- A Preliminary Computational Investigation Into the Flow of PEG in Rat Myocardial Tissue for Regenerative Therapy.Frontiers in cardiovascular medicine · 2019Article
- Successful rebuilding after disaster, even in the heart, starts with infrastructure.Journal of thoracic disease · 2018Article
- Potential Strategies to Address the Major Clinical Barriers Facing Stem Cell Regenerative Therapy for Cardiovascular Disease: A Review.JAMA cardiology · 2016Review
- Finding Expandable Induced Cardiovascular Progenitor Cells.Circulation research · 2016Article
- A novel platelet lysate hydrogel for endothelial cell and mesenchymal stem cell-directed neovascularization.Acta biomaterialia · 2016Article
- Mesenchymal Stromal Cells Improve Renovascular Function in Polycystic Kidney Disease.Cell transplantation · 2015Article
- Molecular imaging of stem cells for the treatment of acute myocardial infarction.International journal of clinical and experimental medicine · 2015Article
- Article
- Stem cell imaging: from bench to bedside.Cell stem cell · 2014Review
- Article
- Cortical bone-derived stem cells: a novel class of cells for myocardial protection.Circulation research · 2013Article
- Noninvasive monitoring of oxidative stress in transplanted mesenchymal stromal cells.JACC. Cardiovascular imaging · 2013Article
- Stem cell therapy for cardiovascular disease: the demise of alchemy and rise of pharmacology.British journal of pharmacology · 2013Review
- A transgenic tri-modality reporter mouse.PloS one · 2013Article
- In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Molecular imaging of stem cells: tracking survival, biodistribution, tumorigenicity, and immunogenicity.Theranostics · 2012Article
- Imaging: guiding the clinical translation of cardiac stem cell therapy.Circulation research · 2011Review
- In vivo bioluminescence for tracking cell fate and function.American journal of physiology. Heart and circulatory physiology · 2011Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDespite ongoing clinical trials, the optimal time for delivery of bone marrow mononuclear cells (BMCs) after myocardial infarction is unclear. We compared the viability and effects of transplanted BMCs on cardiac function in the acute and subacute inflammatory phases of myocardial infarction. METHODS AND
resultsThe time course of acute inflammatory cell infiltration was quantified by FACS analysis of enzymatically digested hearts of FVB mice (n=12) after left anterior descending artery ligation. Mac-1(+)Gr-1(high) neutrophil infiltration peaked at day 4. BMCs were harvested from transgenic FVB mice expressing firefly luciferase (Fluc) and green fluorescent protein (GFP). Afterward, 2.5x10(6) BMCs were injected into the left ventricle of wild-type FVB mice either immediately (acute BMC) or 7 days (subacute BMC) after myocardial infarction, or after a sham procedure (n=8 per group). In vivo bioluminescence imaging showed an early signal increase in both BMC groups at day 7, followed by a nonsignificant trend (P=0.203) toward improved BMC survival in the subacute BMC group that persisted until the bioluminescence imaging signal reached
background<0.01) and 6 weeks (both BMC groups versus saline; P<0.05) but no significant differences between the 2 BMC groups. FACS analysis of BMC-injected hearts at day 7 revealed that GFP(+) BMCs expressed hematopoietic (CD45, Mac-1, Gr-1), minimal progenitor (Sca-1, c-kit), and no endothelial (CD133, Flk-1) or cardiac (Trop-T) cell markers.
conclusionsTiming of BMC delivery has minimal effects on intramyocardial retention and preservation of cardiac function. In general, there is poor long-term engraftment and BMCs tend to adopt inflammatory cell phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.