ArticleNitric oxide : biology and chemistry2010
NO reactions with sol-gel and solution phase samples of the ferric nitrite derivative of HbA.
Article in Nitric oxide : biology and chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- The chemical biology of dinitrogen trioxide.Redox biochemistry and chemistry · 2024Article
- S-Nitrosylated fetal hemoglobin in neonatal human blood.Biochemical and biophysical research communications · 2016Article
- Evaluating the capacity to generate and preserve nitric oxide bioactivity in highly purified earthworm erythrocruorin: a giant polymeric hemoglobin with potential blood substitute properties.The Journal of biological chemistry · 2015Article
- Mechanisms of nitrite bioactivation.Nitric oxide : biology and chemistry · 2014Review
- Routes for formation of S-nitrosothiols in blood.Cell biochemistry and biophysics · 2013Review
- Generating S-nitrosothiols from hemoglobin: mechanisms, conformational dependence, and physiological relevance.The Journal of biological chemistry · 2013Article
- Hemoglobin-mediated nitric oxide signaling.Free radical biology & medicine · 2013Review
- HBOC vasoactivity: interplay between nitric oxide scavenging and capacity to generate bioactive nitric oxide species.Antioxidants & redox signaling · 2013Review
- Nitric oxide formation versus scavenging: the red blood cell balancing act.The Journal of physiology · 2012Review
- Low NO concentration dependence of reductive nitrosylation reaction of hemoglobin.The Journal of biological chemistry · 2012Article
- Effects of T- and R-state stabilization on deoxyhemoglobin-nitrite reactions and stimulation of nitric oxide signaling.Nitric oxide : biology and chemistry · 2011Article
- Structural and functional studies indicating altered redox properties of hemoglobin E: implications for production of bioactive nitric oxide.The Journal of biological chemistry · 2011Article
- Hemoglobin as a nitrite anhydrase: modeling methemoglobin-mediated N2O3 formation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2011Article
- Glass matrix-facilitated thermal reduction: a tool for probing reactions of met hemoglobin with nitrite and nitric oxide.The journal of physical chemistry. B · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The reaction of nitric oxide (NO) with the ferric (met) nitrite derivative of human adult hemoglobin Hb is probed for both solution phase and sol-gel encapsulated populations. The evolution of both the Q band absorption spectrum and fitted populations of Hb derivatives are used to show the sequence of events occurring when NO interacts with nitrite bound to a ferric heme in Hb. The sol-gel is used to compare the evolving populations as a function of quaternary state for the starting met-nitrite populations. The redox status of intermediates is probed using the CN(-) anion to trap ferric heme species. The emergent presence of reactive NO species such as N(2)O(3) during the course of the reaction is probed using the fluorescent probe DAF-2 whereas the fluorophore Chemifluor is used as an indirect measure of the ability of the reaction to create S-nitrosothiols on glutathione. The results are consistent with the formation of a stable reactive intermediate capable of generating bioactive forms of NO. The patterns observed are consistent with a proposed mechanism whereby NO reacts with the ferric nitrite derivative to generate N(2)O(3).
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