ArticleJournal of the American Chemical Society2009
Hydrogen bonding of beta-turn structure is stabilized in D(2)O.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Breaking hydrogen bond network enhances oxygenic photosynthesis of photosystem II.Fundamental research · 2026Article
- Kinetic Isotope Effect in the Unfolding of a Protein Secondary Structure: Calculations for Beta-Sheet Polyglycine Dimers as a Model.Biomolecules · 2025Article
- Effect of Solvent Properties on the Critical Solution Temperature of Thermoresponsive Polymers.International journal of molecular sciences · 2024Article
- Genetically Fusing Order-Promoting and Thermoresponsive Building Blocks to Design Hybrid Biomaterials.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Review
- DThe journal of physical chemistry. B · 2023Review
- Decreased Water Mobility Contributes To Increased α-Synuclein Aggregation.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023Article
- Decreased Water Mobility Contributes To Increased α-Synuclein Aggregation.Angewandte Chemie (International ed. in English) · 2023Article
- Development of truncated elastin-like peptide analogues with improved temperature-response and self-assembling properties.Scientific reports · 2022Article
- Application of Thermoresponsive Intrinsically Disordered Protein Polymers in Nanostructured and Microstructured Materials.Macromolecular bioscience · 2021Review
- What will happen when thermoresponsive poly(RSC advances · 2019Article
- Deuterium induces a distinctiveThe Journal of biological chemistry · 2019Article
- Multifunctional elastin-like polypeptide renders β-glucosidase enzyme phase transition and high stability.Biotechnology for biofuels · 2019Article
- Synthesis of Polylysine/Silica Hybrids through Branched-Polylysine-Mediated Biosilicification.ACS omega · 2018Article
- Author Correction: Injectable tissue integrating networks from recombinant polypeptides with tunable order.Nature materials · 2018Article
- Injectable tissue integrating networks from recombinant polypeptides with tunable order.Nature materials · 2018Article
- Temperature-Induced Collapse of Elastin-like Peptides Studied by 2DIR Spectroscopy.The journal of physical chemistry. B · 2018Article
- Article
- PMMA-Materials (Basel, Switzerland) · 2018Article
- Guanidinium can both Cause and Prevent the Hydrophobic Collapse of Biomacromolecules.Journal of the American Chemical Society · 2017Article
- Designer amphiphilic proteins as building blocks for the intracellular formation of organelle-like compartments.Nature materials · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The lower critical solution temperature (LCST) of elastin-like polypeptides (ELPs) was investigated as a function of ELP chain length and guest residue chemistry. These measurements were made in both D(2)O and H(2)O. Differences in the LCST values with heavy and light water were correlated with secondary structure formation of the polypeptide chains. Such structural information was obtained by circular dichroism and infrared measurements. Additional thermodynamic data were obtained by differential scanning calorimetry. It was found that there is a greater change in the LCST value between H(2)O and D(2)O for those polypeptides which form the greatest amount of beta-turn/beta-aggregate structure. Moreover, these same molecules were the least hydrophobic ELPs. Therefore, hydrogen bonding rather than hydrophobicity was the key factor in the stabilization of the collapsed state of ELPs in D(2)O compared with H(2)O.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.