ArticleThe Journal of clinical investigation1991
Binding of Cryptococcus neoformans by human cultured macrophages. Requirements for multiple complement receptors and actin.
Article in The Journal of clinical investigation, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 115 citations in OpenAlex.
- Macrophage Mediated Immunomodulation DuringFrontiers in cellular and infection microbiology · 2022Review
- Transcriptional Changes in Pulmonary Phagocyte Subsets Dictate the Outcome Following Interaction With The Fungal PathogenFrontiers in immunology · 2021Article
- Vaccine-Induced Immunological Memory in Invasive Fungal Infections - A Dream so Close yet so Far.Frontiers in immunology · 2021Review
- Pulmonary Macrophage and Dendritic Cell Responses toFrontiers in cellular and infection microbiology · 2020Review
- Innate Immune Responses toJournal of fungi (Basel, Switzerland) · 2017Article
- Exploiting fungal cell wall components in vaccines.Seminars in immunopathology · 2015Review
- Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections.Mediators of inflammation · 2015Review
- Host immunity to Cryptococcus neoformans.Future microbiology · 2015Review
- Cryptococcus inositol utilization modulates the host protective immune response during brain infection.Cell communication and signaling : CCS · 2014Article
- Nitrogen source-dependent capsule induction in human-pathogenic cryptococcus species.Eukaryotic cell · 2013Article
- Cryptococcal interactions with the host immune system.Eukaryotic cell · 2010Review
- Influence of mannan and glucan on complement activation and C3 binding by Candida albicans.Infection and immunity · 2010Article
- Murine IgG1 and IgG3 isotype switch variants promote phagocytosis of Cryptococcus neoformans through different receptors.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- App1: an antiphagocytic protein that binds to complement receptors 3 and 2.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Binding of glucuronoxylomannan to the CD14 receptor in human A549 alveolar cells induces interleukin-8 production.Clinical and vaccine immunology : CVI · 2007Article
- Characterization of a flocculation-like phenotype in Cryptococcus neoformans and its effects on pathogenesis.Cellular microbiology · 2006Article
- Role of capsule and interleukin-6 in long-term immune control of Cryptococcus neoformans infection by specifically activated human peripheral blood mononuclear cells.Infection and immunity · 2006Article
- In vivo role of dendritic cells in a murine model of pulmonary cryptococcosis.Infection and immunity · 2006Article
- Immune response and immunotherapy to Cryptococcus infections.Immunologic research · 2006Review
- Opsonic requirements for dendritic cell-mediated responses to Cryptococcus neoformans.Infection and immunity · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We studied the receptors on human cultured macrophages (MO-M phi) responsible for binding encapsulated and isogenic mutant acapsular strains of Cryptococcus neoformans, and whether such binding leads to a phagocytic event. Both strains required opsonization with complement components in normal human serum in order for binding to occur. Binding of the acapsular, but not the encapsulated, strain led to phagocytosis. MAb directed against any of the three defined complement receptors (CR) on MO-M phi (CR1, CR3, and CR4) profoundly inhibited binding of serum-opsonized encapsulated (and to a lesser extent acapsular) organisms to MO-M phi. Immunofluorescence studies demonstrated migration of CR to the area of the cryptococcal binding site. Trypsin and elastase inhibited binding of encapsulated and, to a lesser extent, acapsular yeasts to MO-M phi. Binding of encapsulated C. neoformans was profoundly inhibited by incubation in the cold or by inhibitors of receptor capping and actin microfilaments. Thus, multiple CR appear to contribute to binding of serum-opsonized encapsulated C. neoformans by MO-M phi. Binding is an energy-dependent process that requires conformational changes in actin yet does not lead to phagocytosis of the organism. In contrast, energy is not required for binding of acapsular yeasts by MO-M phi and binding triggers phagocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.