Evidence map›Paper›PMID 19918339›Full record

ArticleReviews in urology2009

Hypocitraturia: pathophysiology and medical management.

Jack M Zuckerman, Dean G Assimos

2 registry-linked trialsAbstract read
PubMed Full text at PMC
In one paragraph

Article in Reviews in urology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 116 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04073719 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Apple Cider Vinegar for the Prevention of Urinary Lithiasis (APUL)

TypeinterventionalSponsorUnited States Naval Medical Center, San DiegoRan2019 to 2022Enrolled50ConditionsKidney Stones, Urolithiasis, HypocitraturiaArmsApple Cider Vinegar, Other Beverage
NCT05511337 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Effect of Control in Oxalate and Citrate Intake on Gut Microbiota Composition in Patients With Urolithiasis: Double-blind Randomized Clinical Study

TypeinterventionalSponsorHospital Regional de Alta Especialidad de la Península de YucatánRan2022 to 2025Enrolled60ConditionsUrolithiasisArmsCaloric restriction and control oxalate and citrate foods, Caloric restriction, Real-life intervention with control oxalate and citrate foods
3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Urolithiasis in patients with cancer.Nature reviews. Urology · 2026
    Review
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  13. Review
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  18. Observational
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jack M ZuckermanDepartment of Urology, Wake Forest University School of Medicine Winston-Salem, NC.
Dean G Assimos

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low urinary citrate excretion is a known risk factor for the development of kidney stones. Citrate inhibits stone formation by complexing with calcium in the urine, inhibiting spontaneous nucleation, and preventing growth and agglomeration of crystals. Hypocitraturia is a common metabolic abnormality found in 20% to 60% of stone formers. It is most commonly idiopathic in origin but may be caused by distal renal tubular acidosis, hypokalemia, bowel dysfunction, and a high-protein, low-alkali diet. Genetic factors, medications, and other comorbid disorders also play a role. Hypocitraturia should be managed through a combination of dietary modifications, oral alkali, and possibly lemonade or other citrus juice-based therapy. This review concerns the pathophysiology of hypocitraturia and the management of stone formers afflicted with this abnormality.

Indexed as

Alkali citrateCitrate metabolismCitrate pathophysiologyCitrus juiceHypocitraturiaHypocitraturia etiologiesLemonadeMedical management of stone diseasePotassium citrate

Identifiers

PMID19918339
PMCPMC2777061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.