ArticleInternational journal of clinical and experimental medicine2009
Increased lysozyme expression in gastric biopsies with intestinal metaplasia and pseudopyloric metaplasia.
Article in International journal of clinical and experimental medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- The origins and progression of pyloric metaplasia following gastric mucosal injury.Physiological reviews · 2026Review
- Lysozyme-Induced Transcriptional Regulation of TNF-α Pathway Genes in Cells of the Monocyte Lineage.International journal of molecular sciences · 2019Article
- Oral delivery of Bacillus subtilis spore expressing enolase of Clonorchis sinensis in rat model: induce systemic and local mucosal immune responses and has no side effect on liver function.Parasitology research · 2015Article
- The Natural Antimicrobial Enzyme Lysozyme is Up-Regulated in Gastrointestinal Inflammatory Conditions.Pathogens (Basel, Switzerland) · 2014Review
- Evaluating the association between histological manifestations of cord colitis syndrome with GVHD.Bone marrow transplantation · 2013Article
- Lysozyme-rich mucus metaplasia in duodenal crypts supersedes Paneth cells in celiac disease.Virchows Archiv : an international journal of pathology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lysozyme is an innate enzyme with potent non-immunological antibacterial properties in the upper intestinal tract. Lysozyme expression (ly-ex) was investigated in 80 consecutive sets of gastric biopsies having normal gastric mucosa (n=20), chronic gastritis (n=20), gastric intestinal metaplasia (IM, n=20), and pseudopyloric metaplasia (PpM, n=20). In biopsies with normal mucosa and with chronic gastritis, the foveolar epithelium and the mucus neck cells of the fundic mucosa as well as the antropyloric glands had moderate (++) to marked (+++) ly-ex whereas the fundic glands proper did not express lysozyme. In IM the goblet and the Paneth cells showed marked (+++) ly-ex. PpM, developing in patients with autoimmune (corpus) gastritis, had moderate ly-ex (++), thus contrasting with the negative ly-ex in the normal or inflamed fundic mucosa. The Helicobacter pylori did not proliferate in areas with IM or with PpM. The lysozyme production in IM and in PpM might be upregulated to eradicate ingested, proliferating bacteria in acid-deficient stomachs.
Indexed as
Identifiers
19918317PMC2773612W1489056735What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.