ArticleJournal of visualized experiments : JoVE2009
Monitoring heart function in larval Drosophila melanogaster for physiological studies.
Article in Journal of visualized experiments : JoVE, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Genetic architecture of basal heart rate and its modulation by dietary salt in Drosophila melanogaster.PLoS genetics · 2026Article
- Do Magnesium Ions Have Similar Effects as Calcium Ions on Resting Membrane Potential?Membranes · 2026Article
- The Effects of Overexpressing K2p Channels in Various Tissues on Physiology and Behaviors.Insects · 2025Article
- The Biphasic Effect of Lipopolysaccharide on Membrane Potential.Membranes · 2025Article
- The Effect of Magnesium Concentration on Myogenic Cardiac Function: LarvalmicroPublication biology · 2024Article
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- Developing Drosophila melanogaster Models for Imaging and Optogenetic Control of Cardiac Function.Journal of visualized experiments : JoVE · 2022Article
- Flexible method for generating needle-shaped beams and its application in optical coherence tomography.Optica · 2022Article
- Examining the effect of manganese on physiological processes: Invertebrate models.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2022Article
- Heat shock proteins and small nucleolar RNAs are dysregulated in a Drosophila model for feline hypertrophic cardiomyopathy.G3 (Bethesda, Md.) · 2021Article
- Effect of Temperature on Heart Rate forInsects · 2021Article
- The effects of tricaine mesylate on arthropods: crayfish, crab and Drosophila.Invertebrate neuroscience : IN · 2020Article
- Impedance Measures and a Mounting Technique for Drosophila: Larval Movements, Heart Rate, Imaging, and Electrophysiology.Methods and protocols · 2020Article
- Article
- Effects of inhibiting mTOR with rapamycin on behavior, development, neuromuscular physiology and cardiac function in larvalBiology open · 2019Article
- Multi-modal and multiscale imaging approaches reveal novel cardiovascular pathophysiology inBiology open · 2019Article
- The Effects of Chloride Flux onMethods and protocols · 2019Article
- Conservation of cardiac L-type CaJournal of molecular and cellular cardiology · 2018Article
- Mechanical stress regulates insulin sensitivity through integrin-dependent control of insulin receptor localization.Genes & development · 2018Article
- Drosophila Preparation and Longitudinal Imaging of Heart Function In Vivo Using Optical Coherence Microscopy (OCM).Journal of visualized experiments : JoVE · 2016Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present various methods to record cardiac function in the larval Drosophila. The approaches allow heart rate to be measured in unrestrained and restrained whole larvae. For direct control of the environment around the heart another approach utilizes the dissected larvae and removal of the internal organs in order to bathe the heart in desired compounds. The exposed heart also allows membrane potentials to be monitored which can give insight of the ionic currents generated by the myocytes and for electrical conduction along the heart tube. These approaches have various advantages and disadvantages for future experiments that are discussed. The larval heart preparation provides an additional model besides the Drosophila skeletal NMJ to investigate the role of intracellular calcium regulation on cellular function. Learning more about the underlying ionic currents that shape the action potentials in myocytes in various species, one can hope to get a handle on the known ionic dysfunctions associated to specific genes responsible for various diseases in mammals.
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