Evidence map›Paper›PMID 19918069›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2010

Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine.

Randolph M Nesse, Carl T Bergstrom, Peter T Ellison, Jeffrey S Flier, Peter Gluckman, Diddahally R Govindaraju, Dietrich Niethammer, Gilbert S Omenn, Robert L Perlman, Mark D Schwartz and 3 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
137.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 222 citations in OpenAlex.

  1. Article
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  8. Evolutionary psychiatry: foundations, progress and challenges.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Evaluating the dissemination of evolutionary biology concepts in medicine.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Innovations are disproportionately likely in the periphery of a scientific network.Theory in biosciences = Theorie in den Biowissenschaften · 2021
    Article
  19. Clan genomics: From OMIM phenotypic traits to genes and biology.American journal of medical genetics. Part A · 2021
    Article
  20. Review

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 4 countries.

Randolph M NesseDepartment of Psychiatry and Psychology, University of Michigan, Room 3018, East Hall, 530 Church Street, Ann Arbor, MI 48104, USA. nesse@umich.edu
Carl T Bergstrom
Peter T Ellison
Jeffrey S Flier
Peter Gluckman
Diddahally R Govindaraju
Dietrich Niethammer
Gilbert S Omenn
Robert L Perlman
Mark D Schwartz
Mark G Thomas
Stephen C Stearns
David Valle
Harvard University · USUniversity of Michigan–Ann Arbor · USBoston University · USJohns Hopkins University · USUniversity Children's Hospital Tübingen · DEUniversity College London · GBUniversity of Auckland · NZUniversity of Chicago · USUniversity of Washington · USVA NY Harbor Healthcare System · USYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New applications of evolutionary biology in medicine are being discovered at an accelerating rate, but few physicians have sufficient educational background to use them fully. This article summarizes suggestions from several groups that have considered how evolutionary biology can be useful in medicine, what physicians should learn about it, and when and how they should learn it. Our general conclusion is that evolutionary biology is a crucial basic science for medicine. In addition to looking at established evolutionary methods and topics, such as population genetics and pathogen evolution, we highlight questions about why natural selection leaves bodies vulnerable to disease. Knowledge about evolution provides physicians with an integrative framework that links otherwise disparate bits of knowledge. It replaces the prevalent view of bodies as machines with a biological view of bodies shaped by evolutionary processes. Like other basic sciences, evolutionary biology needs to be taught both before and during medical school. Most introductory biology courses are insufficient to establish competency in evolutionary biology. Premedical students need evolution courses, possibly ones that emphasize medically relevant aspects. In medical school, evolutionary biology should be taught as one of the basic medical sciences. This will require a course that reviews basic principles and specific medical applications, followed by an integrated presentation of evolutionary aspects that apply to each disease and organ system. Evolutionary biology is not just another topic vying for inclusion in the curriculum; it is an essential foundation for a biological understanding of health and disease.

Indexed as

Biological EvolutionEducation, MedicalBiologyCurriculumHumans

Identifiers

PMID19918069
PMCPMC2868284
OpenAlexW1984990980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.