ArticleDiabetes care2010
Birth weight, body silhouette over the life course, and incident diabetes in 91,453 middle-aged women from the French Etude Epidemiologique de Femmes de la Mutuelle Generale de l'Education Nationale (E3N) Cohort.
Article in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Subjective Evaluation of Female Adult Body Fat Distribution: A Scoping Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Article
- Birth length and perinatal exposures and rheumatoid arthritis risk in the E3N cohort.RMD open · 2026Observational
- Weight changes from early to middle adulthood and cardiometabolic multimorbidity later in life among middle-aged and older adults: a retrospective cohort study from the NHANES 1999-2018.Frontiers in endocrinology · 2024Article
- The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study.Frontiers in endocrinology · 2022Article
- Relationship between Birth Weight, Early Growth Rate, and Body Composition in 5- to 7-Year-Old Children.Obesity facts · 2022Article
- Prenatal Nicotine Exposure Induces Low Birthweight and Hyperinsulinemia in Male Rats.Frontiers in endocrinology · 2021Article
- Beyond recent BMI: BMI exposure metrics and their relationship to health.SSM - population health · 2020Article
- Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study.JAMA network open · 2019Article
- Developmental Programming of Body Composition: Update on Evidence and Mechanisms.Current diabetes reports · 2019Review
- Prenatal Development and Adolescent Obesity: Two Distinct Pathways to Diabetes in Adulthood.Childhood obesity (Print) · 2018Article
- Associations of General and Central Adiposity With Incident Diabetes in Chinese Men and Women.Diabetes care · 2018Article
- Home and Work Physical Activity Environments: Associations with Cardiorespiratory Fitness and Physical Activity Level in French Women.International journal of environmental research and public health · 2016Article
- Effect of low birth weight on women's health.Clinical therapeutics · 2014Review
- Article
- Modeling obesity histories in cohort analyses of health and mortality.Epidemiology (Cambridge, Mass.) · 2013Review
- Age at menarche and risk of type 2 diabetes among African-American and white women in the Atherosclerosis Risk in Communities (ARIC) study.Diabetologia · 2012Article
- Low lung function and risk of type 2 diabetes in Japanese men: the Toranomon Hospital Health Management Center Study 9 (TOPICS 9).Mayo Clinic proceedings · 2012Article
- Changes in BMI, duration of overweight and obesity, and glucose metabolism: 45 years of follow-up of a birth cohort.Diabetes care · 2011Article
- Haemoglobin A1c, fasting glucose and future risk of elevated depressive symptoms over 2 years of follow-up in the English Longitudinal Study of Ageing.Psychological medicine · 2011Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveObesity and increases in body weight in adults are considered to be among the most important risk factors for type 2 diabetes. Low birth weight is also associated with a higher diabetes incidence. We aimed to examine to what extent the evolution of body shape, from childhood to adulthood, is related to incident diabetes in late adulthood. RESEARCH DESIGN AND
methodsEtude Epidemiologique de Femmes de la Mutuelle Générale de l'Education Nationale (E3N) is a cohort study of French women born in 1925-1950 and followed by questionnaire every 2 years. At baseline, in 1990, women were asked to report their current weight, height, and body silhouette at various ages. Birth weight was recorded in 2002. Cases of diabetes were self-reported or obtained by drug reimbursement record linkage and further validated.
resultsOf the 91,453 women who were nondiabetic at baseline, 2,534 developed diabetes over the 15 years of follow-up. Birth weight and body silhouette at 8 years, at menarche, and in young adulthood (20-25 years) were inversely associated with the risk of diabetes, independently of adult BMI during follow-up (all P(trend) < 0.001). In mid-adulthood (35-40 years), the association was reversed, with an increase in risk related to a larger body silhouette. An increase in body silhouette from childhood to mid-adulthood amplified the risk of diabetes.
conclusionsLow birth weight and thinness until young adulthood may increase the risk of diabetes, independently of adult BMI during follow-up. Young women who were lean children should be especially warned against weight gain.
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