ArticleThe Journal of cell biology1991
The axonally secreted protein axonin-1 is a potent substratum for neurite growth.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 146 citations in OpenAlex.
- Role of CNTN6 in neurodevelopment and neuropathology.Frontiers in neuroscience · 2026Review
- Cbln1 regulates axon growth and guidance in multiple neural regions.PLoS biology · 2022Article
- Implication of Contactins in Demyelinating Pathologies.Life (Basel, Switzerland) · 2021Review
- TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation.Cell reports · 2020Article
- Contactins in the central nervous system: role in health and disease.Neural regeneration research · 2019Review
- Ablation of CNTN2+ Pyramidal Neurons During Development Results in Defects in Neocortical Size and Axonal Tract Formation.Frontiers in cellular neuroscience · 2019Article
- Contactin-2/TAG-1, active on the front line for three decades.Cell adhesion & migration · 2017Article
- Glycosylphosphatidylinositol-Anchored Immunoglobulin Superfamily Cell Adhesion Molecules and Their Role in Neuronal Development and Synapse Regulation.Frontiers in molecular neuroscience · 2017Review
- Oxygen radicals elicit paralysis and collapse of spinal cord neuron growth cones upon exposure to proinflammatory cytokines.BioMed research international · 2014Article
- Axonal regeneration after spinal cord injury in zebrafish and mammals: differences, similarities, translation.Neuroscience bulletin · 2013Review
- Distinct cis regulatory elements govern the expression of TAG1 in embryonic sensory ganglia and spinal cord.PloS one · 2013Article
- Article
- The retinal specific CD147 Ig0 domain: from molecular structure to biological activity.Journal of molecular biology · 2011Article
- The effects of Tag-1 on the maturation of mouse cerebellar granule neurons.Cellular and molecular neurobiology · 2011Article
- The expression of TAG-1 in glial cells is sufficient for the formation of the juxtaparanodal complex and the phenotypic rescue of tag-1 homozygous mutants in the CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Axonin-1/TAG-1 is required for pathfinding of granule cell axons in the developing cerebellum.Neural development · 2008Article
- Transient axonal glycoprotein-1 (TAG-1) and laminin-alpha1 regulate dynamic growth cone behaviors and initial axon direction in vivo.Neural development · 2008Article
- Semaphorin6A acts as a gate keeper between the central and the peripheral nervous system.Neural development · 2007Article
- The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction.Protein science : a publication of the Protein Society · 2007Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axonin-1 is a neuronal glycoprotein occurring both as a membrane-bound and a secreted form. Membrane-bound axonin-1 is predominantly located in membranes of developing nerve fiber tracts and has recently been characterized as a cell adhesion molecule; the soluble form is secreted from axons and accumulates in the cerebrospinal fluid and the vitreous fluid of the eye. In the present study, we addressed the question as to whether secreted axonin-1 was released in a functionally competent form and we found that it strongly promotes neurite outgrowth when presented to neurons as an immobilized substratum. Neurite lengths elaborated by embryonic dorsal root ganglia neurons on axonin-1 were similar to those on the established neurite-promoting substrata L1 and laminin. Fab fragments of axonin-1 antibodies completely inhibited neurite growth on axonin-1, but not on other substrata. In soluble form, axonin-1 had an anti-adhesive effect, as revealed by perturbation of neurite fasciculation. In view of their structural similarity, we conclude that secreted and membrane-bound axonin-1 interact with the same growth-promoting neuritic receptor. The fact that secreted axonin-1 is functionally active, together with our previous findings that it is secreted from an internal cellular pool, suggests a functional dualism between membrane-bound and secreted axonin-1 at the site of secretion, which is most likely the growth cone. The secretion of adhesion molecules could represent a powerful and rapidly acting regulatory element of growth cone-neurite interactions in the control of neurite elongation, pathway selection, and possibly target recognition.
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