ArticleThe Journal of cell biology1991
Centrophilin: a novel mitotic spindle protein involved in microtubule nucleation.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 98 citations in OpenAlex.
- A review of research progress of antitumor drugs based on tubulin targets.Translational cancer research · 2020Review
- Mapping Load-Bearing in the Mammalian Spindle Reveals Local Kinetochore Fiber Anchorage that Provides Mechanical Isolation and Redundancy.Current biology : CB · 2017Article
- NuMA after 30 years: the matrix revisited.Trends in cell biology · 2010Review
- Antibodies to mitotic spindle apparatus: clinical significance of NuMA and HsEg5 autoantibodies.Journal of clinical immunology · 2008Article
- NuMA influences higher order chromatin organization in human mammary epithelium.Molecular biology of the cell · 2007Article
- Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs.Molecular biology of the cell · 1998Article
- Opposing motor activities are required for the organization of the mammalian mitotic spindle pole.The Journal of cell biology · 1996Article
- The cell cycle-dependent localization of the CP190 centrosomal protein is determined by the coordinate action of two separable domains.The Journal of cell biology · 1995Article
- NuMA is required for the organization of microtubules into aster-like mitotic arrays.The Journal of cell biology · 1995Article
- Epitope mapping and direct visualization of the parallel, in-register arrangement of the double-stranded coiled-coil in the NuMA protein.The EMBO journal · 1995Article
- Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein.Journal of virology · 1994Article
- Cell cycle dependent distribution of a centrosomal antigen at the perinuclear MTOC or at the kinetochores of higher plant cells.Chromosoma · 1994Article
- CENP-C is required for maintaining proper kinetochore size and for a timely transition to anaphase.The Journal of cell biology · 1994Article
- Nuclear-mitotic apparatus protein: a structural protein interface between the nucleoskeleton and RNA splicing.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- The B1C8 protein is in the dense assemblies of the nuclear matrix and relocates to the spindle and pericentriolar filaments at mitosis.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- In vitro assembly of multiprotein complexes containing alpha, beta, and gamma tubulin, heat shock protein HSP70, and elongation factor 1 alpha.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- NuMA is required for the proper completion of mitosis.The Journal of cell biology · 1993Article
- A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes.The EMBO journal · 1992Article
- MSA-36: a chromosomal and mitotic spindle-associated protein.Chromosoma · 1992Article
- Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis.The Journal of cell biology · 1992Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A novel protein has been identified which may serve a key function in nucleating spindle microtubule growth in mitosis. This protein, called centrophilin, is sequentially relocated from the centromeres to the centrosomes to the midbody in a manner dependent on the mitotic phase. Centrophilin was initially detected by immunofluorescence with a monoclonal, primate-specific antibody (2D3) raised against kinetochore-enriched chromosome extract from HeLa cells (Valdivia, M. M., and B. R. Brinkley. 1985. J. Cell Biol. 101:1124-1134). Centrophilin forms prominent crescents at the poles of the metaphase spindle, gradually diminishes during anaphase, and bands the equatorial ends of midbody microtubules in telophase. The formation and breakdown of the spindle and midbody correlates in time and space with the aggregation and disaggregation of centrophilin foci. Immunogold EM reveals that centrophilin is a major component of pericentriolar material in metaphase. During recovery from microtubule inhibition, centrophilin foci act as nucleation sites for the assembly of spindle tubules. The 2D3 probe recognizes two high molecular mass polypeptides, 180 and 210 kD, on immunoblots of whole HeLa cell extract. Taken together, these data and the available literature on microtubule dynamics point inevitably to a singular model for control of spindle tubule turnover.
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