ArticleThe Journal of cell biology1991
The cytoskeleton of the resting human blood platelet: structure of the membrane skeleton and its attachment to actin filaments.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
70 citing papers in PubMed, 234 citations in OpenAlex.
- Trial
- New insights of glycoprotein Ib-IX-V complex organization and glycoprotein Ibα in platelet biogenesis.Current opinion in hematology · 2024Review
- Article
- Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation.International journal of molecular sciences · 2024Review
- Platelet Proteome Reveals Novel Targets for Hypercoagulation in Pseudoexfoliation Syndrome.International journal of molecular sciences · 2024Article
- Article
- Megakaryocyte buds are distinct from microvesicles and likely to represent platelet precursors.Blood advances · 2023Article
- SHIP1 Controls Internal Platelet Contraction and αInternational journal of molecular sciences · 2023Article
- Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt Activation in Platelets.Molecular and cellular biology · 2023Article
- The GPIb-IX complex on platelets: insight into its novel physiological functions affecting immune surveillance, hepatic thrombopoietin generation, platelet clearance and its relevance for cancer development and metastasis.Experimental hematology & oncology · 2022Review
- A multiscale model for multiple platelet aggregation in shear flow.Biomechanics and modeling in mechanobiology · 2021Article
- Rapid analysis of streaming platelet images by semi-unsupervised learning.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2021Article
- A predictive multiscale model for simulating flow-induced platelet activation: Correlating in silico results with in vitro results.Journal of biomechanics · 2021Article
- Use of electron microscopy to study platelets and thrombi.Platelets · 2020Review
- Localization Microscopy of Actin Cytoskeleton in Human Platelets.International journal of molecular sciences · 2018Article
- Platelets and cancer angiogenesis nexus.Cancer metastasis reviews · 2017Review
- Balance of microtubule stiffness and cortical tension determines the size of blood cells with marginal band across species.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A multiscale biomechanical model of platelets: Correlating with in-vitro results.Journal of biomechanics · 2017Article
- Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation.PloS one · 2016Article
- Cytoskeletal Network Morphology Regulates Intracellular Transport Dynamics.Biophysical journal · 2015Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We used high-resolution EM and immunocytochemistry in combination with different specimen preparation techniques to resolve the ultrastructure of the resting platelet cytoskeleton. The periphery of the cytoskeleton, an electron-dense subplasmalemmal region in thin section electron micrographs, is a tightly woven planar sheet composed of a spectrin-rich network whose interstices contain GPIb/IX-actin-binding protein (ABP) complexes. This membrane skeleton connects to a system of curved actin filaments (F-actin) that emanate from a central oval core of F-actin cross-linked by ABP. The predominant interaction of the radial actin filaments with the membrane skeleton is along their sides, and the strongest connection between the membrane skeleton and F-actin is via ABP-GPIb ligands, although there is evidence for spectrin attaching to the ends of the radial actin filaments as well. Since a mechanical separation of the F-actin cores and radial F-actin-GPIb-ABP complexes from the underlying spectrin-rich skeleton leads to the latter's expansion, it follows that the spectrin-based skeleton of the resting cell may be held in a compressed form by interdigitating GPIb/IX complexes which are immobilized by radial F-actin-ABP anchors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.