Thiazide diuretics alone or with beta-blockers impair glucose metabolism in hypertensive patients with abdominal obesity.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

1. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019
   Guideline
2. Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial.The lancet. Diabetes & endocrinology · 2016
   Trial
3. Angiotensin receptor blocker/diuretic combination preserves insulin responses in obese hypertensives.Journal of hypertension · 2010
   Trial
4. Impact of cancer history on coronary calcification and clinical outcomes in intravascular ultrasound-guided percutaneous coronary intervention.Coronary artery disease · 2026
   Article
5. Antihypertensive therapy in diabetes mellitus: efficacy, safety, and metabolic impacts in type 1 and type 2 diabetes.Cardiovascular diabetology. Endocrinology reports · 2026
   Review
6. The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026
   Article
7. Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors.Cell communication and signaling : CCS · 2025
   Article
8. Impact of Angiotensin-Converting Enzyme Inhibitor on Coronary Artery Calcification Evaluated by Intravascular Ultrasound: A Retrospective Cohort Study.Health science reports · 2025
   Article
9. Treatment options for heart failure in individuals with overweight or obesity: a review.Future cardiology · 2025
   Review
10. Diuretics: a review of the pharmacology and effects on glucose homeostasis.Frontiers in pharmacology · 2025
    Review
11. Different effects of medications for hypertension on renal function between patients with and without diabetes mellitus undergoing percutaneous coronary intervention: a retrospective single-center cohort study.BMC cardiovascular disorders · 2023
    Article
12. Evidence-based complementary and alternative medicine : eCAM · 2020
    Article
13. Drug-induced diabetes type 2: In silico study involving class B GPCRs.PloS one · 2019
    Article
14. Type 2 diabetes mellitus and hypertension: an update.Endocrinology and metabolism clinics of North America · 2014
    Review
15. Gene expression in thiazide diuretic or statin users in relation to incident type 2 diabetes.International journal of molecular epidemiology and genetics · 2014
    Article
16. The effects of antihypertensive drugs on chromium status, glucose metabolism, and antioxidant and inflammatory indices in spontaneously hypertensive rats.Biological trace element research · 2014
    Article
17. Inadequacies of current approaches to prediabetes and diabetes prevention.Endocrine · 2013
    Article
18. Pathophysiology of prediabetes and treatment implications for the prevention of type 2 diabetes mellitus.Endocrine · 2013
    Review
19. Diabetes mellitus and vascular disease.Hypertension (Dallas, Tex. : 1979) · 2013
    Article
20. Nebivolol improves insulin sensitivity in the TGR(Ren2)27 rat.Metabolism: clinical and experimental · 2011
    Article

Corrections and comments

• Comment on
  Impact of abdominal obesity on incidence of adverse metabolic effects associated with antihypertensive medications.2010

Authors and funding

3 authors at 1 institution in 1 country.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as