ArticleMolecular and cellular biology2010
Asymmetric microtubule function is an essential requirement for polarized organization of the Drosophila bristle.
Article in Molecular and cellular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Osteocyte Dendrites: How Do They Grow, Mature, and Degenerate in Mineralized Bone?Cytoskeleton (Hoboken, N.J.) · 2025Review
- NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.The Journal of cell biology · 2024Article
- Role of BicDR in bristle shaft construction and support of BicD functions.Journal of cell science · 2024Article
- Crustacean leg regeneration restores complex microanatomy and cell diversity.Science advances · 2022Article
- Scale-type-specific requirement for the mosquito Aedes aegypti Spindle-F homologue by regulating microtubule organization.Insect molecular biology · 2022Article
- Novel Doublesex Duplication Associated with Sexually Dimorphic Development of Dogface Butterfly Wings.Molecular biology and evolution · 2021Article
- Dynein Heavy Chain 64C Differentially Regulates Cell Survival and Proliferation of Wingless-Producing Cells inJournal of developmental biology · 2021Article
- Developmental, cellular and biochemical basis of transparency in clearwing butterflies.The Journal of experimental biology · 2021Article
- Rab11 activation by Ik2 kinase is required for dendrite pruning in Drosophila sensory neurons.PLoS genetics · 2020Article
- GFP-Forked, a genetic reporter for studyingBiology open · 2019Article
- IKKε inhibits PKC to promote Fascin-dependent actin bundling.Development (Cambridge, England) · 2016Article
- Coordination of autophagosome-lysosome fusion and transport by a Klp98A-Rab14 complex in Drosophila.Journal of cell science · 2016Article
- Dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways.Biology open · 2015Article
- Spindle-F Is the Central Mediator of Ik2 Kinase-Dependent Dendrite Pruning in Drosophila Sensory Neurons.PLoS genetics · 2015Article
- A transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation.Development (Cambridge, England) · 2015Article
- Exploring the molecular basis of monarch butterfly color pattern variation: a response to A. Hume's 'Myosin--a monarch of pigment transport?'.Pigment cell & melanoma research · 2015Article
- Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like.Molecular and cellular biology · 2013Article
- Dusky-like functions as a Rab11 effector for the deposition of cuticle during Drosophila bristle development.Development (Cambridge, England) · 2012Article
- The Drosophila javelin gene encodes a novel actin-associated protein required for actin assembly in the bristle.Molecular and cellular biology · 2011Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While previous studies have shown that microtubules (MTs) are essential for maintaining the highly biased axial growth of the Drosophila bristle, the mechanism for this process has remained vague. We report that the MT minus-end marker, Nod-KHC, accumulates at the bristle tip, suggesting that the MT network in the bristle is organized minus end out. Potential markers for studying the importance of properly polarized MTs to bristle axial growth are Ik2 and Spindle-F (Spn-F), since mutations in spn-F and ik2 affect bristle development. We demonstrate that Spn-F and Ik2 are localized to the bristle tip and that mutations in ik2 and spn-F affect bristle MT and actin organization. Specifically, mutation in ik2 affects polarized bristle MT function. It was previously found that the hook mutant exhibited defects in bristle polarity and that hook is involved in endocytic trafficking. We found that Hook is localized at the bristle tip and that this localization is affected in ik2 mutants, suggesting that the contribution of MTs within the bristle shaft is important for correct endocytic trafficking. Thus, our results show that MTs are organized in a polarized manner within the highly elongated bristle and that this organization is essential for biased bristle axial growth.
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