ArticleInfection and immunity2010
Porphyromonas gingivalis ferrous iron transporter FeoB1 influences sensitivity to oxidative stress.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Biochemical and functional characterization ofFrontiers in microbiology · 2026Article
- Exploring heme and iron acquisition strategies of Porphyromonas gingivalis-current facts and hypotheses.FEMS microbiology reviews · 2025Review
- Defining the role of Hmu and Hus systems in Porphyromonas gingivalis heme and iron homeostasis and virulence.Scientific reports · 2024Article
- The cadDX operon contributes to cadmium resistance, oxidative stress resistance, and virulence in zoonotic streptococci.Veterinary research · 2024Article
- Comparative analysis ofMicrobiology spectrum · 2024Article
- Functional Characterization of FeoAB in Iron Acquisition and Pathogenicity in Riemerella anatipestifer.Microbiology spectrum · 2023Article
- Interspecies Inhibition ofApplied and environmental microbiology · 2019Article
- Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells.Journal of visualized experiments : JoVE · 2015Article
- Article
- The Yfe and Feo transporters are involved in microaerobic growth and virulence of Yersinia pestis in bubonic plague.Infection and immunity · 2012Article
- FeoB2 Functions in magnetosome formation and oxidative stress protection in Magnetospirillum gryphiswaldense strain MSR-1.Journal of bacteriology · 2012Article
- Role of the Porphyromonas gingivalis extracytoplasmic function sigma factor, SigH.Molecular oral microbiology · 2012Article
- Oxidative stress resistance in Porphyromonas gingivalis.Future microbiology · 2012Review
- The capsule of Porphyromonas gingivalis leads to a reduction in the host inflammatory response, evasion of phagocytosis, and increase in virulence.Infection and immunity · 2011Article
- Antibacterial action of polyphosphate on Porphyromonas gingivalis.Antimicrobial agents and chemotherapy · 2011Article
- Characterization of a hemophore-like protein from Porphyromonas gingivalis.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Porphyromonas gingivalis FeoB1 is a ferrous iron transporter. Analysis of parental and feoB1-deficient strains of the periodontal pathogen revealed that the feoB1-deficient mutant strain had an increased ability to survive oxidative stress. Specifically, survival of the mutant strain was increased 33% with exposure to peroxide and 5% with exposure to atmospheric oxygen compared to the parental strain. Interestingly, the ability to survive intracellularly also increased fivefold in the case of the feoB1-deficient mutant. Our data suggest that although the FeoB1 protein is required for ferrous iron acquisition in P. gingivalis, it also has an adverse effect on survival of the bacterium under oxidative stress conditions. Finally, we show that feoB1 expression is not iron dependent and is dramatically reduced in the presence of host cells, consistent with the observed deleterious role it plays in bacterial survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.