ArticleJournal of neuroscience methods2010
Correlation of locomotor activity and brain infarction in rats with transient focal ischemia.
Article in Journal of neuroscience methods, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Elevated body swing test after focal cerebral ischemia in rodents: methodological considerations.BMC neuroscience · 2015Pooled it
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- 3,6'- and 1,6'-Dithiopomalidomide Mitigate Ischemic Stroke in Rats and Blunt Inflammation.Pharmaceutics · 2022Article
- Anti-apoptotic activity of ETScientific reports · 2019Article
- Neurotrophic and neuroprotective effects of oxyntomodulin in neuronal cells and a rat model of stroke.Experimental neurology · 2017Article
- Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model.Neuroscience · 2015Article
- Time-Dependent Protection of CB2 Receptor Agonist in Stroke.PloS one · 2015Article
- Article
- Manual versus Automated Rodent Behavioral Assessment: Comparing Efficacy and Ease of Bederson and Garcia Neurological Deficit Scores to an Open Field Video-Tracking System.Journal of central nervous system disease · 2014Article
- Unilateral hemispherectomy at adulthood asymmetrically affects motor performance of male Swiss mice.Experimental brain research · 2012Article
- Post-treatment with amphetamine enhances reinnervation of the ipsilateral side cortex in stroke rats.NeuroImage · 2011Article
- Widespread cortical expression of MANF by AAV serotype 7: localization and protection against ischemic brain injury.Experimental neurology · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Occlusion of middle cerebral artery (MCAo) is commonly used to generate stroke in experimental animals. Different behavioral assays have been used to evaluate the severity of lesions or recovery after treatment in this model. In this study, we examined the correlation between the size of infarction and locomotor activity after transient MCAo in adult Sprague-Dawley rats. The right middle cerebral artery was occluded for 30-90-min by ligation with a 10-O suture. At 2 days after MCAo, animals were individually placed in a 3-D infrared activity chamber for 1h to measure their horizontal, vertical, stereotypic and rotational activity. Body asymmetry was examined using an elevated body swing test. Volume of infarction was measured by triphenyltetrazolium chloride staining. We found that there is a significant correlation between the volume of infarction and vertical movement, such as vertical activity, vertical movement number and vertical movement time. There is also a significant correlation between the infarction volume and body asymmetry. In conclusion, our data suggest that vertical locomotor activity and body asymmetry are useful behavioral indices to estimate the size of lesioning in rodents after MCAo.
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Registered trials
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