Evidence map›Paper›PMID 19917244›Full record

ArticleMolecular cell2009

BAX and BAK caught in the act.

Yong Yao, Francesca M Marassi

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. The selective BH4-domain biology of Bcl-2-family members: IP3Rs and beyond.Cellular and molecular life sciences : CMLS · 2013
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yong YaoBurnham Institute for Medical Research, La Jolla, CA 92037, USA.
Francesca M Marassi
Sanford Burnham Prebys Medical Discovery Institute · US

Funding

Structures of membrane-bound Bcl-2 apoptotic proteinsR01GM065374 · NIGMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MARASSI, FRANCESCA M · 2005 to 2009
$1.3M
NIGMS NIH HHS R01 GM065374
6 · The paper itself

Abstract

In this issue of Molecular Cell, Kim et al. (2009) describe the steps involved in the direct activation of the proapoptotic proteins BAX and BAK by their BH3-only partners, resolving the controversy regarding direct versus indirect activation of these proteins.

Indexed as

ApoptosisAnimalsApoptosis Regulatory Proteinsbcl-2-Associated X Proteinbcl-2 Homologous Antagonist-Killer ProteinBcl-2-Like Protein 11BH3 Interacting Domain Death Agonist ProteinCells, CulturedFibroblastsMembrane ProteinsMiceMice, KnockoutMitochondriaModels, BiologicalProtein BindingProtein MultimerizationApoptosis Regulatory ProteinsBak1 protein, mouseBax protein, mousebcl-2-Associated X Proteinbcl-2 Homologous Antagonist-Killer ProteinBcl2l11 protein, mouseBcl-2-Like Protein 11BH3 Interacting Domain Death Agonist ProteinMembrane ProteinsProto-Oncogene ProteinsPUMA protein, mouseTumor Suppressor Proteins

Identifiers

PMID19917244
PMCPMC2897738
OpenAlexW1966184710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.