ArticleMolecular cell2009
p53 and Metabolism: The GAMT Connection.
Article in Molecular cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Aging and cancer: current understandings and future perspectives.Signal transduction and targeted therapy · 2026Review
- The oxidoreductase p66Shc acts as tumor suppressor in BRAFV600E-transformed cells.Molecular oncology · 2018Article
- cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation.Scientific reports · 2016Article
- Tumor suppressor p53 and its mutants in cancer metabolism.Cancer letters · 2015Review
- Autophagy-mediated tumor promotion.Cell · 2013Review
- Dysregulation of the mTOR pathway in p53-deficient mice.Cancer biology & therapy · 2013Article
- Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis.Genes & development · 2013Article
- p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity.Cell death and differentiation · 2013Article
- Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?Aging · 2012Article
- Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype.PloS one · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this issue of Molecular Cell, Ide et al. (2009) have identified the enzyme guanidinoacetate methyltransferase (GAMT) that regulates creatine metabolism as a p53 target involved in apoptosis, reactive oxygen species (ROS), and fatty acid metabolism.
Indexed as
Identifiers
19917243What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.