ArticleBiophysical journal2009
Controlling the orientation and synaptic differentiation of myotubes with micropatterned substrates.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 54 citations in OpenAlex.
- Shaping 3D minimal model tissues with mechanical constraints to orchestrate muscle differentiation.Communications biology · 2025Article
- Three-Dimensional Microfibrous Scaffold with Aligned Topography Produced via a Combination of Melt-Extrusion Additive Manufacturing and Porogen Leaching for In Vitro Skeletal Muscle Modeling.Bioengineering (Basel, Switzerland) · 2024Article
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- 3D Bioprinting and In Vitro Cardiovascular Tissue Modeling.Bioengineering (Basel, Switzerland) · 2017Review
- Nanostructured scaffold as a determinant of stem cell fate.Stem cell research & therapy · 2016Review
- Anisotropic Materials for Skeletal-Muscle-Tissue Engineering.Advanced materials (Deerfield Beach, Fla.) · 2016Review
- On-chip, multisite extracellular and intracellular recordings from primary cultured skeletal myotubes.Scientific reports · 2016Article
- In situ cross-linked electrospun fiber scaffold of collagen for fabricating cell-dense muscle tissue.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2016Article
- Bridging the Gap: From 2D Cell Culture to 3D Microengineered Extracellular Matrices.Advanced healthcare materials · 2015Review
- Review
- Nanotopography-guided tissue engineering and regenerative medicine.Advanced drug delivery reviews · 2013Review
- Engineering muscle tissues on microstructured polyelectrolyte multilayer films.Tissue engineering. Part A · 2012Article
- Engineering skeletal muscle tissue--new perspectives in vitro and in vivo.Journal of cellular and molecular medicine · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Micropatterned poly(dimethylsiloxane) substrates fabricated by soft lithography led to large-scale orientation of myoblasts in culture, thereby controlling the orientation of the myotubes they formed. Fusion occurred on many chemically identical surfaces in which varying structures were arranged in square or hexagonal lattices, but only a subset of patterned surfaces yielded aligned myotubes. Remarkably, on some substrates, large populations of myotubes oriented at a reproducible acute angle to the lattice of patterned features. A simple geometrical model predicts the angle and extent of orientation based on maximizing the contact area between the myoblasts and patterned topographic surfaces. Micropatterned substrates also provided short-range cues that influenced higher-order functions such as the localization of focal adhesions and accumulation of postsynaptic acetylcholine receptors. Our results represent what we believe is a new approach for musculoskeletal tissue engineering, and our model sheds light on mechanisms of myotube alignment in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.