ArticleBiophysical journal2009
Effectiveness of hair bundle motility as the cochlear amplifier.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- The continued importance of comparative auditory research to modern scientific discovery.Hearing research · 2023Review
- The Competition between the Noise and Shear Motion Sensitivity of Cochlear Inner Hair Cell Stereocilia.Biophysical journal · 2018Article
- Finite-element model of the active organ of Corti.Journal of the Royal Society, Interface · 2016Article
- The physiology of mechanoelectrical transduction channels in hearing.Physiological reviews · 2014Review
- Modelling cochlear mechanics.BioMed research international · 2014Review
- A prestin motor in chicken auditory hair cells: active force generation in a nonmammalian species.Neuron · 2013Article
- Effects of cochlear loading on the motility of active outer hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Multiple-timescale dynamics underlying spontaneous oscillations of saccular hair bundles.Biophysical journal · 2011Article
- Coupling active hair bundle mechanics, fast adaptation, and somatic motility in a cochlear model.Biophysical journal · 2011Article
- Somatic motility and hair bundle mechanics, are both necessary for cochlear amplification?Hearing research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The effectiveness of hair bundle motility in mammalian and avian ears is studied by examining energy balance for a small sinusoidal displacement of the hair bundle. The condition that the energy generated by a hair bundle must be greater than energy loss due to the shear in the subtectorial gap per hair bundle leads to a limiting frequency that can be supported by hair-bundle motility. Limiting frequencies are obtained for two motile mechanisms for fast adaptation, the channel re-closure model and a model that assumes that fast adaptation is an interplay between gating of the channel and the myosin motor. The limiting frequency obtained for each of these models is an increasing function of a factor that is determined by the morphology of hair bundles and the cochlea. Primarily due to the higher density of hair cells in the avian inner ear, this factor is approximately 10-fold greater for the avian ear than the mammalian ear, which has much higher auditory frequency limit. This result is consistent with a much greater significance of hair bundle motility in the avian ear than that in the mammalian ear.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.