ArticleReproductive biology and endocrinology : RB&E2009
Up-regulation of CatSper genes family by selenium.
Article in Reproductive biology and endocrinology : RB&E, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Exploring the Impacts of Fluoride-Induced Thyroid Toxicity: A Comprehensive Review.Biological trace element research · 2026Review
- <p>Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene</p>.Molecular medicine reports · 2026Article
- Calcium Channels and Modulators as Potential Therapeutic Targets for Contraceptives and Male Fertility: A Scoping Review.Open access journal of contraception · 2025Review
- Protamine1, 2 and Catsper1: sperm quality and fertility indicators in Stallions.Animal reproduction · 2025Article
- A comprehensive review on potential role of selenium, selenoproteins and selenium nanoparticles in male fertility.Heliyon · 2024Review
- The Chemosensing Role of CatSper in Mammalian Sperm: An Updated Review.Current issues in molecular biology · 2023Review
- Testicular aging, male fertility and beyond.Frontiers in endocrinology · 2022Review
- Up-regulation of Arl4a gene expression by broccoli aqueous extract is associated with improved spermatogenesis in mouse testes.Biomedica : revista del Instituto Nacional de Salud · 2021Article
- Roles of CatSper channels in the pathogenesis of asthenozoospermia and the therapeutic effects of acupuncture-like treatment on asthenozoospermia.Theranostics · 2021Article
- Effect of experimental hyperthyroidism onInternational journal of reproductive biomedicine · 2020Article
- Comparative effects of nano-selenium and sodium selenite supplementations on fertility in aged broiler breeder males.Veterinary research forum : an international quarterly journal · 2020Article
- Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice.Antioxidants (Basel, Switzerland) · 2019Article
- Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences.Antioxidants (Basel, Switzerland) · 2019Review
- Alteration inInternational journal of reproductive biomedicine · 2018Article
- Intramembranal disulfide cross-linking elucidates the super-quaternary structure of mammalian CatSpers.Reproductive biology · 2018Article
- Analysis of the correlation of CATSPER single nucleotide polymorphisms (SNPs) with idiopathic asthenospermia.Journal of assisted reproduction and genetics · 2015Article
- Evaluating the effects of Escanbil (Calligonum) extract on the expression level of Catsper gene variants and sperm motility in aging male mice.Iranian journal of reproductive medicine · 2014Article
- Effects of Vitamin-E treatment on CatSper genes expression and sperm quality in the testis of the aging mouse.Iranian journal of reproductive medicine · 2013Article
- Effect of selenium on neurotoxicity in adult male mice exposed to formaldehyde.Electronic physicianArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCatSper1-4 are a unique family of sperm cation channels, which are exclusively expressed in the testis and play an important role in sperm motility and male fertility. Despite their vital role in male fertility, almost nothing is known about the factors regulating their expression. Here, we investigated the effects of selenium (Se) on the expression of CatSper genes and sperm parameters in aging versus young male mice.
methodsForty 11-13 months aging male mice and forty 2-3 months young adult male mice were used. The animals were divided in two experimental groups: first group including aging males and second group comprising of young adult males, both treated with Se. The experimental groups were injected intra-peritoneally with Se (0.2 mg/kg) daily, for up to 5 weeks. Two other groups, aging and young adult mice without Se treatment were used as controls. All the animals were rapidly sacrificed by cervical dislocation on the days 21, 28, 35 and 42 after Se treatment. Subsequently, the morphology of the collected sperms was analyzed, and one of the testes from each mouse used for semi-quantitative RT-PCR. The significancy of the data was analyzed using ANOVA. RESULTS AND DISCUSSION: Our data revealed that there was a significant up-regulation of CatSper genes in the experimental groups compared to the control ones. Furthermore, the results of sperm analysis showed that the sperm parameters were improved in the aging as well as young adult male mice following Se treatment.
conclusionSe treatment in the aging subjects could up-regulate the expression of CatSper genes, and therefore results in elevation of sperm motility. Furthermore, Se treatment improved sperm parameters, especially morphology and viability rates.
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