ReviewBMC medicine2009
Migraine pathogenesis and state of pharmacological treatment options.
Review in BMC medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Levetiracetam as preventive treatment in adults with migraine: an up-to-date systematic review and quantitative meta-analysis.European journal of clinical pharmacology · 2020Pooled it
- Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) for the prevention of migraine in adults.The Cochrane database of systematic reviews · 2015Pooled it
- Identifying neural oscillation and phase synchronization abnormalities in migraine and their predictive values in transcranial magnetic stimulation.Journal of oral & facial pain and headache · 2026Article
- Quickest way to less headache days: an operational research model and its implementation for chronic migraine.BMC neurology · 2025Article
- Prospective Matched Case-Control Study of Over-Early P100 Wave Latency in Migraine with Aura.Biomedicines · 2023Article
- Trends in utilization and costs of migraine medications, 2017-2020.The journal of headache and pain · 2022Article
- Association of dietary diversity score (DDS) and migraine headache severity among women.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- The Association Between Blood Pressure and Headache in Postmenopausal Women: A Prospective Hospital-Based Study.International journal of general medicine · 2021Article
- Neuropeptide changes in an improved migraine model with repeat stimulations.Translational neuroscience · 2021Article
- Cortical potentiation induced by calcitonin gene-related peptide (CGRP) in the insular cortex of adult mice.Molecular brain · 2020Article
- Review
- Article
- Photophobia: When Light Hurts, a Review.Current neurology and neuroscience reports · 2018Review
- Current Prophylactic Medications for Migraine and Their Potential Mechanisms of Action.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- The effect of intracerebroventricular injection of CGRP on pain behavioral responses and monoamines concentrations in the periaqueductal gray area in rat.Iranian journal of basic medical sciences · 2018Article
- Rorschach Evaluation of Personality and Emotional Characteristics in Adolescents With Migraine Versus Epilepsy and Controls.Frontiers in neurology · 2018Article
- Photophobia in neurologic disorders.Translational neurodegeneration · 2017Review
- Concussion in the Military: an Evidence-Base Review of mTBI in US Military Personnel Focused on Posttraumatic Headache.Current pain and headache reports · 2016Review
- A comparison of outcome of medical and surgical treatment of migraine headache: In 1 year follow-up.Advanced biomedical research · 2016Article
- Multi-frequency analysis of brain connectivity networks in migraineurs: a magnetoencephalography study.The journal of headache and pain · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a largely inherited disorder of the brain characterized by a complex, but stereotypical, dysfunction of sensory processing. Often the most obvious clinical symptom is head pain, but non-headache symptoms such as photophobia, phonophobia and nausea are clearly part of the typical presentation. This review discusses the current pathophysiological concepts of migraine and migraine aura, such as a possible brainstem dysfunction and cortical spreading depression. Acute and preventive migraine treatment approaches are briefly covered with a focus on shortcomings of the currently available treatment options. A number of different receptors, such as calcitonin gene-related peptide (CGRP), TRPV1 and glutamate receptors, are currently being targeted by potential novel migraine therapeutics. The prospects of this research are exciting and are likely to improve patient care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.