ReviewClinical infectious diseases : an official publication of the Infectious Diseases Society of America2009
Universal antiretroviral therapy for pregnant and breast-feeding HIV-1-infected women: towards the elimination of mother-to-child transmission of HIV-1 in resource-limited settings.
Review in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01061151 (Breastfeeding Version of the PROMISE Study), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Breastfeeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Antiretroviral interventions for preventing breast milk transmission of HIV.The Cochrane database of systematic reviews · 2014Pooled it
- Integrating antiretroviral therapy into antenatal care and maternal and child health settings: a systematic review and meta-analysis.Bulletin of the World Health Organization · 2013Pooled it
- Pooled it
- Morbidity and mortality among infants born to HIV-infected women in South Africa: implications for child health in resource-limited settings.Journal of tropical pediatrics · 2011Trial
- Effect of vitamin supplements on HIV shedding in breast milk.The American journal of clinical nutrition · 2010Trial
- Genital tract infections, antiretroviral treatment and HIV-1 viral load in early postpartum women: : implications for sexual and breastfeeding HIV transmission.BMC infectious diseases · 2026Article
- Economic evaluation of Maternal Depression Treatment in HIV (M-DEPTH) for perinatal depression among women living with HIV in Uganda: a cost-effectiveness analysis.BMJ public health · 2024Article
- 2023 updated guidelines on infant feeding and HIV in the United States: what are they and why have recommendations changed.Topics in antiviral medicine · 2023Article
- Reduced neuronal population in the dorsolateral prefrontal cortex in infant macaques infected with simian immunodeficiency virus (SIV).Journal of neurovirology · 2021Article
- Summary of 2021 Clinical Guidelines for the Diagnosis and Treatment of HIV/AIDS in HIV-infected Koreans.Infection & chemotherapy · 2021Review
- Hippocampal Neuronal Loss in Infant Macaques Orally Infected with Virulent Simian Immunodeficiency Virus (SIV).Brain sciences · 2017Article
- Describing Point of Entry into Care and Being Lost to Program in a Cohort of HIV Positive Pregnant Women in a Large Urban Centre in Uganda.AIDS research and treatment · 2017Article
- Impact of Population Recruitment on the HIV Epidemics and the Effectiveness of HIV Prevention Interventions.Bulletin of mathematical biology · 2016Article
- Nurses’ compliance with prevention of mother-to-child transmission national guidelines in selected sites in Kinshasa, Democratic Republic of Congo.African journal of primary health care & family medicine · 2015Article
- Understanding HIV compartments and reservoirs.Current HIV/AIDS reports · 2014Review
- The impact of a HIV prevention of mother to child transmission program in a nigerian early infant diagnosis centre.Nigerian medical journal : journal of the Nigeria Medical Association · 2014Article
- Prevalence of drug resistance in human immunodeficiency virus type 1-infected treatment-naive children in Pune, India.AIDS research and human retroviruses · 2014Article
- Diagnosis and Management of Cryptococcal Relapse.Journal of AIDS & clinical research · 2013Article
- Socio-economic, clinical and biological risk factors for mother - to - child transmission of HIV-1 in Muhima health centre (Rwanda): a prospective cohort study.Archives of public health = Archives belges de sante publique · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prevention of mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1) remains a challenge in most resource-limited settings, particularly in Africa. Single-dose and short-course antiretroviral (ARV) regimens are only partially effective and have failed to achieve wide coverage despite their apparent simplicity. More potent ARV combinations are restricted to pregnant women who need treatment for themselves and are also infrequently used. Furthermore, postnatal transmission via breast-feeding is a serious additional threat. Modifications of infant feeding practices aim to reduce HIV-1 transmission through breast milk; replacement feeding is neither affordable nor safe for the majority of African women, and early breast-feeding cessation (eg, prior to 6 months of life) requires substantial care and nutritional counseling to be practiced safely. The recent roll out of ARV treatment has changed the paradigm of prevention of MTCT. To date, postnatal ARV interventions that have been evaluated target either maternal ARV treatment to selected breast-feeding women, with good efficacy, or single-drug postexposure prophylaxis for short periods of time to their neonates, with a partial efficacy and at the expense of acquisition of drug-related viral resistance. We hypothesize that a viable solution to eliminate pediatric AIDS lies in the universal provision of fully suppressive ARV regimens to all HIV-1-infected women through pregnancy, delivery, and the entire breast-feeding period. On the basis of available evidence, we suggest translating into practice the recently available evidence on this matter without any further delay.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.