ArticlePsychopharmacology2010
Amphetamine analogs methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) differentially affect speech.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- MDMA enhances positive affective responses to social feedback.Journal of psychopharmacology (Oxford, England) · 2024Trial
- The Blinded-Dose Purchase Task: assessing hypothetical demand based on cocaine, methamphetamine, and alcohol administration.Psychopharmacology · 2023Trial
- Detection of acute 3,4-methylenedioxymethamphetamine (MDMA) effects across protocols using automated natural language processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Intimate insight: MDMA changes how people talk about significant others.Journal of psychopharmacology (Oxford, England) · 2015Trial
- MDMA: a social drug in a social context.Psychopharmacology · 2015Trial
- A window into the intoxicated mind? Speech as an index of psychoactive drug effects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- In the company of others: social factors alter acute alcohol effects.Psychopharmacology · 2013Trial
- Amphetamine as a social drug: effects of d-amphetamine on social processing and behavior.Psychopharmacology · 2012Trial
- Interrogating roles for VTA dopamine neurons in locomotion and ultrasonic vocalizations elicited by different classes of rewarding drugs.Psychopharmacology · 2026Article
- Social Psychopharmacology: Novel Approaches to Treat Deficits in Social Motivation in Schizophrenia.Schizophrenia bulletin · 2023Review
- Methamphetamine administration dose effects on sexual desire, sexual decision making, and delay discounting.Experimental and clinical psychopharmacology · 2022Article
- Analysis of recreational psychedelic substance use experiences classified by substance.Psychopharmacology · 2022Article
- Considering the context: social factors in responses to drugs in humans.Psychopharmacology · 2018Review
- The effects of MDMA on socio-emotional processing: Does MDMA differ from other stimulants?Journal of psychopharmacology (Oxford, England) · 2016Review
- Drug effects on responses to emotional facial expressions: recent findings.Behavioural pharmacology · 2015Review
- Acute Effects of the Novel Psychoactive Drug 2C-B on Emotions.BioMed research international · 2015Article
- MDMA alters emotional processing and facilitates positive social interaction.Psychopharmacology · 2014Article
- Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors.Frontiers in behavioral neuroscience · 2014Article
- Is cognitive functioning impaired in methamphetamine users? A critical review.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Review
- A direct comparison of the behavioral and physiological effects of methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in humans.Psychopharmacology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleMost reports of the effects of methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) on speech have been anecdotal.
objectivesThe current study used a within-participant design to assess the effects of methamphetamine and MDMA on speech. MATERIALS AND
methodsEleven recreational users of amphetamines completed this inpatient, within-participant, double-blind study, during which they received placebo, methamphetamine (20, 40 mg), and MDMA (100 mg) on separate days. Following drug administration, study participants described movies viewed the previous evening and completed mood scales.
resultsMethamphetamine increased quantity of speech, fluency, and self-ratings of talkativeness and alertness, while it decreased the average duration of nonjuncture unfilled pauses. MDMA decreased fluency and increased self-ratings of inability to concentrate. To determine if methamphetamine- and MDMA-related effects were perceptible, undergraduates listened to the participants' movie descriptions and rated their coherence and the speaker's mood. Following methamphetamine, descriptions were judged to be more coherent and focused than they were following MDMA.
conclusionsMethamphetamine improved verbal fluency and MDMA adversely affected fluency. This pattern of effects is consistent with the effects of these drugs on functioning in other cognitive domains. In general, methamphetamine effects on speech were inconsistent with effects popularly attributed to this drug, while MDMA-related effects were in agreement with some anecdotal reports and discordant with others.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.