ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2010
Systemic properties of metabolic networks lead to an epistasis-based model for heterosis.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Back to the future 2: the implications of germplasm structure on the balance between short- and long-term genetic gain in a changing target population of environments.G3 (Bethesda, Md.) · 2026Article
- Quantitative Insights into the Genetic Mechanisms of Crop Heterosis.Advanced genetics (Hoboken, N.J.) · 2025Review
- Transcriptome Analysis of Reciprocal Hybrids Between Crassostrea gigas and C. angulata Reveals the Potential Mechanisms Underlying Thermo-Resistant Heterosis.Marine biotechnology (New York, N.Y.) · 2023Article
- Dynamic patterns of gene expression and regulatory variation in the maize seed coat.BMC plant biology · 2023Article
- Article
- Epistasis Activation Contributes Substantially to Heterosis in Temperate by Tropical Maize Hybrids.Frontiers in plant science · 2022Article
- Haplotype associated RNA expression (HARE) improves prediction of complex traits in maize.PLoS genetics · 2021Article
- Improved redox homeostasis owing to the up-regulation of one-carbon metabolism and related pathways is crucial for yeast heterosis at high temperature.Genome research · 2021Article
- Article
- Dominance Effects and Functional Enrichments Improve Prediction of Agronomic Traits in Hybrid Maize.Genetics · 2020Article
- Heterosis Breeding in Eggplant (Plants (Basel, Switzerland) · 2020Review
- Nonlinear phenotypic variation uncovers the emergence of heterosis in Arabidopsis thaliana.PLoS biology · 2019Article
- Decoupling the Variances of Heterosis and Inbreeding Effects Is Evidenced in Yeast's Life-History and Proteomic Traits.Genetics · 2019Article
- Simulation of heterosis in a genome-scale metabolic network provides mechanistic explanations for increased biomass production rates in hybrid plants.NPJ systems biology and applications · 2019Article
- Heterosis Is a Systemic Property Emerging From Non-linear Genotype-Phenotype Relationships: Evidence FromFrontiers in genetics · 2018Article
- Omics-based hybrid prediction in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- A Systems Approach to Elucidate Heterosis of Protein Abundances in Yeast.Molecular & cellular proteomics : MCP · 2015Article
- A Boolean gene regulatory model of heterosis and speciation.BMC evolutionary biology · 2015Article
- Only one health, and so many omics.Cancer cell international · 2015Article
- Genomic and epigenetic insights into the molecular bases of heterosis.Nature reviews. Genetics · 2013Review
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3 authors.
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Abstract
The genetic and molecular approaches to heterosis usually do not rely on any model of the genotype-phenotype relationship. From the generalization of Kacser and Burns' biochemical model for dominance and epistasis to networks with several variable enzymes, we hypothesized that metabolic heterosis could be observed because the response of the flux towards enzyme activities and/or concentrations follows a multi-dimensional hyperbolic-like relationship. To corroborate this, we used the values of systemic parameters accounting for the kinetic behaviour of four enzymes of the upstream part of glycolysis, and simulated genetic variability by varying in silico enzyme concentrations. Then we "crossed" virtual parents to get 1,000 hybrids, and showed that best-parent heterosis was frequently observed. The decomposition of the flux value into genetic effects, with the help of a novel multilocus epistasis index, revealed that antagonistic additive-by-additive epistasis effects play the major role in this framework of the genotype-phenotype relationship. This result is consistent with various observations in quantitative and evolutionary genetics, and provides a model unifying the genetic effects underlying heterosis.
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