ArticleFrontiers in molecular neuroscience2009
Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators.
Article in Frontiers in molecular neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Differential Expression Patterns of Lynx Proteins and Involvement of Lynx1 in Prepulse Inhibition.Frontiers in behavioral neuroscience · 2021Article
- Multidimensional Intersection of Nicotine, Gene Expression, and Behavior.Frontiers in behavioral neuroscience · 2021Article
- The prototoxin LYPD6B modulates heteromeric α3β4-containing nicotinic acetylcholine receptors, but not α7 homomers.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Membrane-tethered ligands: tools for cell-autonomous pharmacological manipulation of biological circuits.Physiology (Bethesda, Md.) · 2013Review
- Emerging approaches to probing ion channel structure and function.Neuroscience bulletin · 2012Review
- Tethering toxins and peptide ligands for modulation of neuronal function.Current opinion in neurobiology · 2012Review
- Cross-reactivity of acid-sensing ion channel and Na⁺-H⁺ exchanger antagonists with nicotinic acetylcholine receptors.The Journal of physiology · 2011Article
- Frontiers in molecular neuroscience - résumé and perspective.Frontiers in molecular neuroscience · 2011Article
- The Terebridae and teretoxins: Combining phylogeny and anatomy for concerted discovery of bioactive compounds.BMC chemical biology · 2010Article
- An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors.The Journal of physiology · 2010Article
- Silencing neurotransmission with membrane-tethered toxins.Nature methods · 2010Article
- Genetic techniques and circuit analysis.Frontiers in molecular neuroscience · 2010Article
- Neurotrapping: cellular screens to identify the neural substrates of behavior in Drosophila.Frontiers in molecular neuroscience · 2009Article
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Authors and funding
4 authors.
Funding
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Abstract
Neuronal circuits depend on the precise regulation of cell-surface receptors and ion channels. An ongoing challenge in neuroscience research is deciphering the functional contribution of specific receptors and ion channels using engineered modulators. A novel strategy, termed "tethered toxins", was recently developed to characterize neuronal circuits using the evolutionary derived selectivity of venom peptide toxins and endogenous peptide ligands, such as lynx1 prototoxins. Herein, the discovery and engineering of cell-surface tethered peptides is reviewed, with particular attention given to their cell-autonomy, modular composition, and genetic targeting in different model organisms. The relative ease with which tethered peptides can be engineered, coupled with the increasing number of neuroactive venom toxins and ligand peptides being discovered, imply a multitude of potentially innovative applications for manipulating neuronal circuits and tissue-specific cell networks, including treatment of disorders caused by malfunction of receptors and ion channels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.