ArticleFrontiers in cellular neuroscience2009
Regularity, variability and bi-stability in the activity of cerebellar purkinje cells.
Article in Frontiers in cellular neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 29 citations in OpenAlex.
- Climbing Fibers Provide Graded Error Signals in Cerebellar Learning.Frontiers in systems neuroscience · 2019Article
- Complex Electroresponsive Dynamics in Olivocerebellar Neurons Represented With Extended-Generalized Leaky Integrate and Fire Models.Frontiers in computational neuroscience · 2019Article
- Long Pauses in Cerebellar Interneurons in Anesthetized Animals.Cerebellum (London, England) · 2017Article
- Transcranial Alternating Current Stimulation (tACS) Mechanisms and Protocols.Frontiers in cellular neuroscience · 2017Review
- Inverse Stochastic Resonance in Cerebellar Purkinje Cells.PLoS computational biology · 2016Article
- Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization.Frontiers in cellular neuroscience · 2015Article
- Bidirectional modulation of deep cerebellar nuclear cells revealed by optogenetic manipulation of inhibitory inputs from Purkinje cells.Neuroscience · 2014Article
- Emergence of a 600-Hz buzz UP state Purkinje cell firing in alert mice.Neuroscience · 2014Article
- Enhanced synaptic inhibition disrupts the efferent code of cerebellar Purkinje neurons in leaner Cav2.1 Ca 2+ channel mutant mice.Cerebellum (London, England) · 2012Article
- Dendritic calcium signaling triggered by spontaneous and sensory-evoked climbing fiber input to cerebellar Purkinje cells in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Signals and circuits in the purkinje neuron.Frontiers in neural circuits · 2011Article
- Interneurons of the cerebellar cortex toggle Purkinje cells between up and down states.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- High-Pass Filtering and Dynamic Gain Regulation Enhance Vertical Bursts Transmission along the Mossy Fiber Pathway of Cerebellum.Frontiers in cellular neuroscience · 2010Article
- Rebuilding cerebellar network computations from cellular neurophysiology.Frontiers in cellular neuroscience · 2010Article
- Model-founded explorations of the roles of molecular layer inhibition in regulating purkinje cell responses in cerebellar cortex: more trouble for the beam hypothesis.Frontiers in cellular neuroscience · 2010Article
- A Signal Processing Analysis of Purkinje Cells in vitro.Frontiers in neural circuits · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have demonstrated that the membrane potential of Purkinje cells is bi-stable and that this phenomenon underlies bi-modal simple spike firing. Membrane potential alternates between a depolarized state, that is associated with spontaneous simple spike firing (up state), and a quiescent hyperpolarized state (down state). A controversy has emerged regarding the relevance of bi-stability to the awake animal, yet recordings made from behaving cat Purkinje cells have demonstrated that at least 50% of the cells exhibit bi-modal firing. The robustness of the phenomenon in vitro or in anaesthetized systems on the one hand, and the controversy regarding its expression in behaving animals on the other hand suggest that state transitions are under neuronal control. Indeed, we have recently demonstrated that synaptic inputs can induce transitions between the states and suggested that the role of granule cell input is to control the states of Purkinje cells rather than increase or decrease firing rate gradually. We have also shown that the state of a Purkinje cell does not only affect its firing but also the waveform of climbing fiber-driven complex spikes and the associated calcium influx. These findings call for a reconsideration of the role of Purkinje cells in cerebellar function. In this manuscript we review the recent findings on Purkinje cell bi-stability and add some analyses of its effect on the regularity and variability of Purkinje cell activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.