ArticleJournal of molecular structure2008
The linkage between ribosomal crystallography, metal ions, heteropolytungstates and functional flexibility.
Article in Journal of molecular structure, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- A Microscale Platform for the Comprehensive Analysis of Bacterial Translation Initiation.International journal of molecular sciences · 2026Article
- Polyoxotungstates reloaded for renewable fuels.Nature chemistry · 2026Article
- Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH.Nature communications · 2024Article
- Article
- An intrinsically disordered nascent protein interacts with specific regions of the ribosomal surface near the exit tunnel.Communications biology · 2021Article
- Beyond Charge Balance: Counter-Cations in Polyoxometalate Chemistry.Angewandte Chemie (International ed. in English) · 2020Review
- Stress response as implemented by hibernating ribosomes: a structural overview.The FEBS journal · 2019Review
- Exploring Wells-Dawson Clusters Associated With the Small Ribosomal Subunit.Frontiers in chemistry · 2019Article
- The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarials.Malaria journal · 2018Article
- Decavanadate Inhibits Mycobacterial Growth More Potently Than Other Oxovanadates.Frontiers in chemistry · 2018Article
- The fluctuating ribosome: thermal molecular dynamics characterized by neutron scattering.Scientific reports · 2016Article
- The Synthesis and Characterization of Aromatic Hybrid Anderson-Evans POMs and their Serum Albumin Interactions: The Shift from Polar to Hydrophobic Interactions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
- The use of polyoxometalates in protein crystallography - An attempt to widen a well-known bottleneck.Coordination chemistry reviews · 2015Review
- Hen egg-white lysozyme crystallisation: protein stacking and structure stability enhanced by a Tellurium(VI)-centred polyoxotungstate.Chembiochem : a European journal of chemical biology · 2015Article
- Localization and orientation of heavy-atom cluster compounds in protein crystals using molecular replacement.Acta crystallographica. Section D, Biological crystallography · 2013Article
- Large facilities and the evolving ribosome, the cellular machine for genetic-code translation.Journal of the Royal Society, Interface · 2009Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Crystallography of ribosomes, the universal cell nucleoprotein assemblies facilitating the translation of the genetic-code into proteins, met with severe problems owing to their large size, complex structure, inherent flexibility and high conformational variability. For the case of the small ribosomal subunit, which caused extreme difficulties, post crystallization treatment by minute amounts of a heteropolytungstate cluster allowed structure determination at atomic resolution. This cluster played a dual role in ribosomal crystallography: providing anomalous phasing power and dramatically increased the resolution, by stabilization of a selected functional conformation. Thus, four out of the fourteen clusters that bind to each of the crystallized small subunits are attached to a specific ribosomal protein in a fashion that may control a significant component of the subunit internal flexibility, by "gluing" symmetrical related subunits. Here we highlight basic issues in the relationship between metal ions and macromolecules and present common traits controlling in the interactions between polymetalates and various macromolecules, which may be extended towards the exploitation of polymetalates for therapeutical treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.