ArticleOncogene2010
FLASH degradation in response to UV-C results in histone locus bodies disruption and cell-cycle arrest.
Article in Oncogene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Reshuffling Overcrowded Milieu: Stress-Induced Reorganization of the Eukaryotic Membrane-Less Organelles.Sub-cellular biochemistry · 2025Review
- Nucleolar structure connects with global nuclear organization.Molecular biology of the cell · 2023Article
- Article
- A guide to membraneless organelles and their various roles in gene regulation.Nature reviews. Molecular cell biology · 2023Review
- Reorganization of Cell Compartmentalization Induced by Stress.Biomolecules · 2022Review
- Knockout of the caspase 8-associated protein 2 gene improves recombinant protein expression in HEK293 cells through up-regulation of the cyclin-dependent kinase inhibitor 2A gene.Biotechnology and bioengineering · 2021Article
- Higher order genomic organization and regulatory compartmentalization for cell cycle control at the G1/S-phase transition.Journal of cellular physiology · 2018Review
- Intranuclear and higher-order chromatin organization of the major histone gene cluster in breast cancer.Journal of cellular physiology · 2018Article
- Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body.RNA biology · 2017Review
- Droplet organelles?The EMBO journal · 2016Review
- Transcriptome Analysis of Cultured Limbal Epithelial Cells on an Intact Amniotic Membrane following Hypothermic Storage in Optisol-GS.Journal of functional biomaterials · 2016Article
- SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2.Cell cycle (Georgetown, Tex.) · 2013Article
- UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochores.Cell cycle (Georgetown, Tex.) · 2013Article
- A sequence in the Drosophila H3-H4 Promoter triggers histone locus body assembly and biosynthesis of replication-coupled histone mRNAs.Developmental cell · 2013Article
- FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription.Oncogene · 2012Article
- Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.Molecular cancer · 2012Article
- PIAS1 interacts with FLASH and enhances its co-activation of c-Myb.Molecular cancer · 2011Article
- Interactions of CstF-64, CstF-77, and symplekin: implications on localisation and function.Molecular biology of the cell · 2011Article
- The nucleolus under stress.Molecular cell · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Eucaryotic cell nuclei contain a number of different organelles that are highly dynamic structures and respond to a variety of stimuli. Here we investigated the effect of UV irradiation on a recently identified group of organelles, Histone Locus Bodies. Histone Locus Bodies contain at least two main proteins, FLASH and NPAT, and have been shown to be involved in replication-dependent histone gene transcription. We show that these organelles are disrupted after sublethal irradiation and both FLASH and NPAT are degraded, which in turn results in cell-cycle arrest at the S/G2 transition. The effect on the cell cycle is due to reduced transcription of histone genes and restoring normal histone protein levels by stabilizing histone mRNA allows cells to progress through the cell cycle. This provides a novel mechanism of S-phase arrest in response to DNA damage that potentially allows DNA repair before cells continue into mitosis, and thus prevents transmission of genomic alterations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.