ArticleThe Plant cell2009
Dof5.6/HCA2, a Dof transcription factor gene, regulates interfascicular cambium formation and vascular tissue development in Arabidopsis.
Article in The Plant cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed, 184 citations in OpenAlex.
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- Dof Transcription Factors as Integrative Regulatory Hubs Linking Carbon-Nitrogen Metabolism, Development, and Environmental Signaling in Plants.Plant, cell & environment · 2026Review
- Single-nucleus transcriptome profiling unveils cell-type-specific ethylene and TOR signaling in tomato.Horticulture research · 2026Article
- Single-cell and spatial transcriptomics in Phragmites australis reveal the association of B chromosomes with plant invasiveness.Genome biology · 2026Article
- Comparative transcriptomic and transcript-based network analyses revealed genotype-specific alternative splicing induced by Sclerotinia sclerotiorum in Brassica napus.BMC plant biology · 2026Article
- OsDof1 enhances rice (Oryza sativa L.) lodging resistance through suppression of tryptophan-dependent auxin biosynthesis.BMC genomics · 2026Article
- JULGI coordinates vascular development and leaf patterning through non-cell-autonomous regulation of miR165/166.Nature communications · 2026Article
- Single-nuclei sequencing of Moricandia arvensis reveals bundle sheath cell function in the photorespiratory shuttle of C3-C4 intermediate Brassicaceae.Journal of experimental botany · 2025Article
- One organ to infect them all: the Cuscuta haustorium.Annals of botany · 2025Review
- Structural insights into CDF1 accumulation on the CONSTANS promoter via a plant-specific DNA-binding domain.Nature plants · 2025Article
- Strigolactone insensitivity affects the hormonal homeostasis in barley.Scientific reports · 2025Article
- Identification and functional analysis of the Dof transcription factor genes in sugar beet.Journal of plant research · 2025Article
- The molecular framework balancing growth and defense in response to plant elicitor peptide-induced signals in Arabidopsis.The Plant cell · 2024Article
- Imaging Metabolic Flow of Water in Plants with Isotope-Traced Stimulated Raman Scattering Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Single-cell transcriptomic analysis of flowering regulation and vernalization in Chinese cabbage shoot apex.Horticulture research · 2024Article
- Advances in understanding the graft healing mechanism: a review of factors and regulatory pathways.Horticulture research · 2024Article
- Transcription factor ZmDof22 enhances drought tolerance by regulating stomatal movement and antioxidant enzymes activities in maize (Zea mays L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Comprehensive integration of single-cell transcriptomic data illuminates the regulatory network architecture of plant cell fate specification.Plant diversity · 2024Article
- DOF gene family expansion and diversification.Genetics and molecular biology · 2024Article
37 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular cambium, a type of lateral meristem, is the source of secondary xylem and secondary phloem, but little is known about the molecular mechanisms of its formation and development. Here, we report the characterization of an Arabidopsis thaliana gain-of-function mutant with dramatically increased cambial activity, designated high cambial activity2 (hca2). The hca2 mutant has no alternative organization of the vascular bundles/fibers in inflorescence stems, due to precocious formation of interfascicular cambium and its subsequent cell division. The phenotype results from elevated expression of HCA2, which encodes a nuclear-localized DNA binding with one finger (Dof) transcription factor Dof5.6. Dof5.6/HCA2 is preferentially expressed in the vasculature of all the organs, particularly in the cambium, phloem, and interfascicular parenchyma cells of inflorescence stems. Dominant-negative analysis further demonstrated that both ubiquitous and in situ repression of HCA2 activity led to disruption of interfascicular cambium formation and development in inflorescence stems. In-depth anatomical analysis showed that HCA2 promotes interfascicular cambium formation at a very early stage of inflorescence stem development. This report demonstrates that a transcription factor gene, HCA2, is involved in regulation of interfascicular cambium formation and vascular tissue development in Arabidopsis.
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