ArticleJournal of bacteriology2010
Requirements for germination of Clostridium sordellii spores in vitro.
Article in Journal of bacteriology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
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- Microbial Food Safety of Sous Vide Cooking Processes of Chicken and Eggs.Foods (Basel, Switzerland) · 2024Article
- Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs.Communications biology · 2024Article
- Mechanism of germination inhibition of Clostridioides difficile spores by an aniline substituted cholate derivative (CaPA).The Journal of antibiotics · 2023Article
- Comparison of sporulation and germination conditions forFrontiers in microbiology · 2023Article
- Persistent bacteremia and psoas abscess caused by a lethal toxin-deficient Paeniclostridiumsordellii.Anaerobe · 2022Article
- Mechanisms and Applications of Bacterial Sporulation and Germination in the Intestine.International journal of molecular sciences · 2022Review
- Hierarchical recognition of amino acid co-germinants during Clostridioides difficile spore germination.Anaerobe · 2018Article
- Conservation of the "Outside-in" Germination Pathway inFrontiers in microbiology · 2018Article
- Inhibitory effect of indole analogs against Paenibacillus larvae, the causal agent of American foulbrood disease.Journal of insect science (Online) · 2017Article
- Role of stereospecific nature of germinants in3 Biotech · 2017Article
- AThe Journal of biological chemistry · 2017Article
- Germinants and Their Receptors in Clostridia.Journal of bacteriology · 2016Review
- Detecting Cortex Fragments During Bacterial Spore Germination.Journal of visualized experiments : JoVE · 2016Article
- Functional characterisation of germinant receptors in Clostridium botulinum and Clostridium sporogenes presents novel insights into spore germination systems.PLoS pathogens · 2014Article
- Requirements for in vitro germination of Paenibacillus larvae spores.Journal of bacteriology · 2013Article
- Article
- Transcriptional analysis of temporal gene expression in germinating Clostridium difficile 630 endospores.PloS one · 2013Article
- Both fidaxomicin and vancomycin inhibit outgrowth of Clostridium difficile spores.Antimicrobial agents and chemotherapy · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clostridium sordellii is a spore-forming, obligately anaerobic, Gram-positive bacterium that can cause toxic shock syndrome after gynecological procedures. Although the incidence of C. sordellii infection is low, it is fatal in most cases. Since spore germination is believed to be the first step in the establishment of Bacilli and Clostridia infections, we analyzed the requirements for C. sordellii spore germination in vitro. Our data showed that C. sordellii spores require three structurally different amino acids and bicarbonate for maximum germination. Unlike the case for Bacilli species, d-alanine had no effect on C. sordellii spore germination. C. sordellii spores germinated only in a narrow pH range between 5.7 and 6.5. In contrast, C. sordellii spore germination was significantly less sensitive to temperature changes than that of the Bacilli. The analysis of the kinetics of C. sordellii spore germination showed strong allosteric behavior in the binding of l-phenylalanine and l-alanine but not in that of bicarbonate or l-arginine. By comparing germinant apparent binding affinities to their known in vivo concentrations, we postulated a mechanism for differential C. sordellii spore activation in the female reproductive tract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.