Evidence map›Paper›PMID 19914697›Full record

ArticleUrology2010

Polymorphisms in hOGG1 and XRCC1 and risk of prostate cancer: effects modified by plasma antioxidants.

Jianjun Zhang, Ishwori B Dhakal, Graham Greene, Nicholas P Lang, Fred F Kadlubar

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Urology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 14 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 14 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. hOGG1 rs1052133 Polymorphism and Prostate Cancer Risk: A Chinese Case-Control Study and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2022
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  7. Dietary polyphenols in prevention and treatment of prostate cancer.International journal of molecular sciences · 2015
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  15. Selenium- or Vitamin E-Related Gene Variants, Interaction with Supplementation, and Risk of High-Grade Prostate Cancer in SELECT.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016
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  18. Altered memory CCR6EBioMedicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jianjun ZhangDepartment of Public Health, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. jz21@iupui.edu
Ishwori B Dhakal
Graham Greene
Nicholas P Lang
Fred F Kadlubar
University of Arkansas for Medical Sciences · USIndiana University School of Medicine

Funding

PROSTATE CANCER--EXPOSURE, SUSCEPTIBILITY AND DNA ADDUCTR01AG015722 · NIA · UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK · PI LANG, NICHOLAS PAUL · 1997 to 2001
$759k
NIA NIH HHS 1R01AG15722NIA NIH HHS R01 AG015722
6 · The paper itself

Abstract

objectivesTo investigate whether polymorphisms in genes involved in the repair of oxidative DNA damage, modulate, and/or interact with antioxidants to influence prostate cancer risk in a population-based case-control study in Central Arkansas. Accumulating evidence indicates that oxidative stress plays a role in prostate carcinogenesis.

methodsCases (n = 193) included men aged 40-80 years, diagnosed with prostate cancer in 3 major hospitals in 1998-2003, and controls (n = 197) were matched to cases by age, race, and county of residence.

resultsAfter adjustment for confounders, subjects who were heterozygous or homozygous for the variant allele of the hOGG1 Ser326Cys polymorphism appeared to experience a lower risk of prostate cancer than those who were homozygous for the wild-type allele (odds ratio [OR] (95% confidence interval [CI]): 0.72 (0.46-1.10)]. Conversely, a significant increased risk was observed for individuals who carried 1 or 2 copies of the variant allele of the XRCC1 Arg399Gln polymorphism, compared with those who only harbored the wild-type allele (OR [95% CI]: 1.56 [1.01-2.45]). The above-mentioned associations were generally more pronounced among subjects with low plasma carotenoids or alpha-tocopherol (<median). Among subjects who had low plasma levels of beta-cryptoxanthin (<73 microg/L), possession of at least 1 copy of the XRCC1 399Gln allele conferred a greater than 2-fold elevated risk (OR [95% CI]: 2.64 [1.40-5.07]).

conclusionsOur study offers preliminary but intriguing data suggesting that variability in the capacity of repairing oxidative DNA damage influences susceptibility to prostate cancer and that these effects are modified by antioxidants.

Indexed as

Polymorphism, GeneticAdultAgedAged, 80 and overAntioxidantsCase-Control StudiesDNA-Binding ProteinsDNA GlycosylasesDNA RepairHumansMaleMiddle AgedProstatic NeoplasmsRisk FactorsX-ray Repair Cross Complementing Protein 1AntioxidantsDNA-Binding ProteinsDNA Glycosylasesoxoguanine glycosylase 1, humanX-ray Repair Cross Complementing Protein 1XRCC1 protein, human

Identifiers

PMID19914697
PMCPMC2850942
OpenAlexW2094849751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.