Evidence map›Paper›PMID 19914662›Full record

Trial reportThe Journal of urology2010

Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer.

William J Aronson, R James Barnard, Stephen J Freedland, Susanne Henning, David Elashoff, Patricia M Jardack, Pinchas Cohen, David Heber, Naoko Kobayashi

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of urology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00020995 (Effects of a Low Fat Diet on Serum Factors and Prostate Cancer), which is not on this map. Cited by 56 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 6 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00020995 phase2completednot on this map

Effects of a Low Fat Diet on Serum Factors and Prostate Cancer

TypeinterventionalSponsorJonsson Comprehensive Cancer CenterRan2001 to 2010ConditionsProstate CancerArmstherapeutic dietary intervention
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 6 syntheses or guidelines pooled it, 95 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

William J AronsonUrology Section, Department of Surgery, Veterans Administration, Greater Los Angeles Healthcare System, Los Angeles, California 90095-1738, USA. waronson@ucla.edu
R James Barnard
Stephen J Freedland
Susanne Henning
David Elashoff
Patricia M Jardack
Pinchas Cohen
David Heber
Naoko Kobayashi
University of California, Los Angeles · USDuke Medical Center · US

Funding

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
UCLA SPORE IN PROSTATE CANCERP50CA092131 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREEMAN, MICHAEL R · 2002 to 2023
$42.6M
Tea Polyphenols in Chemoprevention of Prostate CancerR01CA116242 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HENNING, SUSANNE MARGARETE · 2007 to 2011
$1.3M
NCI NIH HHS 1R01CA1162-42-01NCI NIH HHS P50 CA092131NCI NIH HHS P50CA 92131-01A1NCI NIH HHS R01 CA116242NCRR NIH HHS M01 RR000865NCRR NIH HHS M01-RR00865
6 · The paper itself

Abstract

purposeA high fat Western diet and sedentary lifestyle may predispose men to prostate cancer through changes in serum hormones and growth factors. We evaluated the effect of a low fat diet on serum factors affecting prostate cancer cell growth by performing a prospective, randomized dietary intervention trial in men with prostate cancer. MATERIALS AND

methodsWe randomized 18 men with prostate cancer who did not receive prior therapy to a low fat (15% kcal), high fiber, soy protein supplemented diet or a Western (40% kcal fat) diet for 4 weeks. Fasting serum was collected at baseline and after the intervention to measure prostate specific antigen, sex hormones, insulin, insulin-like growth factor I and II, insulin-like growth factor binding proteins, lipids and fatty acids. LNCaP cells (ATCC(R)) were cultured in medium containing pre-intervention and post-intervention human serum to assess the in vitro effect of the diet on prostate cancer cell proliferation.

resultsSubjects in each group were highly compliant with the dietary intervention. Serum from men in the low fat group significantly decreased the growth of LNCaP cells relative to Western diet serum (p = 0.03). There were no significant between group changes in serum prostate specific antigen, sex hormones, insulin, insulin-like growth factor I and II, and insulin-like growth factor binding proteins. Serum triglyceride and linoleic acid (omega-6) levels were decreased in the low fat group (p = 0.034 and 0.005, respectively). Correlation analysis revealed that decreased omega-6 and increased omega-3 fatty acid correlated with decreased serum stimulated LNCaP cell growth (r = 0.64, p = 0.004 and r = -0.49, p = 0.04, respectively).

conclusionsIn this prospective, randomized dietary intervention trial a low fat diet resulted in changes in serum fatty acid levels that were associated with decreased human LNCaP cancer cell growth. Further prospective trials are indicated to evaluate the potential of low fat diets for prostate cancer prevention and treatment.

Indexed as

Cell ProliferationDiet, Fat-RestrictedFeasibility StudiesHumansMaleMiddle AgedProspective StudiesProstatic NeoplasmsTumor Cells, Cultured

Identifiers

PMID19914662
PMCPMC3089950
OpenAlexW2106208417

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.