ArticleCellular immunology2010
BAFF overexpression promotes anti-dsDNA B-cell maturation and antibody secretion.
Article in Cellular immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Serum levels of APRIL, BAFF, and IL-10 in systemic lupus erythematosus have limited utility as biomarkers for disease activity or flare prediction.Clinical rheumatology · 2026Article
- The role of B cell-activating factor system in autoimmune diseases: mechanisms, disease implications, and therapeutic advances.Frontiers in immunology · 2025Review
- Lupus and recurrent pregnancy loss: the role of female sex hormones and B cells.Frontiers in endocrinology · 2023Review
- Paradoxical role of Breg-inducing cytokines in autoimmune diseases.Journal of translational autoimmunity · 2019Review
- Sjogren's syndrome: Review of the aetiology, Pathophysiology & Potential therapeutic interventions.Journal of clinical and experimental dentistry · 2017Review
- Transgenic overexpression of BAFF regulates the expression of immune-related genes in zebrafish, Danio rerio.Journal of genetics · 2016Article
- Role of BAFF in pulmonary autoantibody responses induced by chronic cigarette smoke exposure in mice.Physiological reports · 2016Article
- The BAFFling effects of rituximab in lupus: danger ahead?Nature reviews. Rheumatology · 2016Review
- Elevated serum levels of B-cell activating factor in pediatric renal transplant patients.Pediatric nephrology (Berlin, Germany) · 2012Article
- BLyS-mediated modulation of naive B cell subsets impacts HIV Env-induced antibody responses.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps.The Journal of allergy and clinical immunology · 2011Article
- BAFF and selection of autoreactive B cells.Trends in immunology · 2011Review
- Regulation of the B cell receptor repertoire and self-reactivity by BAFF.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Overexpression of BAFF is believed to play an important role in systemic lupus erythematosus and elevated levels of serum BAFF have been found in lupus patients. Excess BAFF also leads to overproduction of anti-dsDNA antibodies and a lupus-like syndrome in mice. In the present study, we use mice transgenic for the R4A-Cmu (IgM) heavy chain of an anti-dsDNA antibody, to study the effects of BAFF overexpression on anti-dsDNA B-cell regulation. We observe that overexpression of BAFF promotes anti-dsDNA B-cell maturation and secretion of antibody and enriches for transgenic anti-dsDNA B cells in the marginal zone and follicular splenic compartments. In addition, our data suggests that BAFF rescues a subset of anti-dsDNA B cells from a regulatory checkpoint in the transitional stage of development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.