ReviewSteroids2010
Review of the Y chromosome, Sry and hypertension.
Review in Steroids, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Endogenous and exogenous determinants of sex differences in blood pressure.NPJ cardiovascular health · 2026Review
- Y Chromosome Genes May Play Roles in the Development of Neural Rosettes from Human Embryonic Stem Cells.Stem cell reviews and reports · 2022Article
- Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR).Clinical science (London, England : 1979) · 2021Review
- Chromosome-Scale Genome of Masked Palm Civet (Frontiers in genetics · 2021Article
- Mitochondrial dysfunction in acute kidney injury and sex-specific implications.Medical research archives · 2019Article
- Fetal programming of adrenal PNMT and hypertension by glucocorticoids in WKY rats is dose and sex-dependent.PloS one · 2019Article
- Sex: A Significant Risk Factor for Neurodevelopmental and Neurodegenerative Disorders.Brain sciences · 2018Review
- Article
- The Y chromosome: a blueprint for men's health?European journal of human genetics : EJHG · 2017Review
- Aberrant activation of the human sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice.Scientific reports · 2017Article
- Sex Hormones and Sex Chromosomes Cause Sex Differences in the Development of Cardiovascular Diseases.Arteriosclerosis, thrombosis, and vascular biology · 2017Review
- Y-chromosomal genes affecting male fertility: A review.Veterinary world · 2016Review
- CAGn repeat of the androgen receptor is linked to proopiomelanocortin promoter methylation-relevance for craving of male alcohol-dependent patients?Psychopharmacology · 2014Article
- Cell-autonomous sex determination outside of the gonad.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Review
- Sex differences in stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Review
- Amino acid function and docking site prediction through combining disease variants, structure alignments, sequence alignments, and molecular dynamics: a study of the HMG domain.BMC bioinformatics · 2012Article
- Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome.Lancet (London, England) · 2012Article
- The end of gonad-centric sex determination in mammals.Trends in genetics : TIG · 2012Article
- Alterations in vasomotor systems and mechanics of resistance-sized mesenteric arteries from SHR and WKY male rats following in vivo testosterone manipulation.Biology of sex differences · 2012Article
- From rat to human: regulation of Renin-Angiotensin system genes by sry.International journal of hypertension · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The following review examines the role of the SHR Y chromosome and specifically the Sry gene complex in hypertension and potential mechanisms that involve the sympathetic nervous system and renin-angiotensin system. There are consistent gender differences in hypertension, with a greater proportion of males affected than females in most mammalian populations. Our earlier studies demonstrated that a portion of the gender differences in blood pressure (BP) in the SHR rat mapped to the SHR Y chromosome. In rats, males with the SHR Y chromosome have higher BP than females, or males with a different Y chromosome. Consistent with these results, several human population studies have confirmed a Y chromosome effect on BP. Our more recent studies focus on a transcription factor, Sry, as the locus involved in not only BP modulation but effects on other phenotypes. The Sry locus is an evolutionarily conserved locus on the mammalian Y chromosome responsible for testis determination and is a transcription factor. The Sry locus contains a highly conserved High Mobility Group (HMG) box region responsible for DNA binding. Mutations in the HMG box result in sex reversal. We have found multiple functional copies of Sry in SHR and WKY male rats. There is abundant evidence that testes determination may not be Sry's only function as it is expressed in the brain, kidney and adrenal gland of adult males. These findings have potential implications for gender physiology research which involves, the sympathetic nervous system, renin-angiotensin system, androgen receptor regulation and prostate physiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.