Evidence map›Paper›PMID 19914241›Full record

ReviewFEBS letters2010

Beyond ribosome rescue: tmRNA and co-translational processes.

Christopher S Hayes, Kenneth C Keiler

Abstract readReview
In one paragraph

Review in FEBS letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
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  5. Review
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  8. Review
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  11. Article
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  14. Article
  15. Mechanisms of ribosome rescue in bacteria.Nature reviews. Microbiology · 2015
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christopher S HayesDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106-9610, USA.
Kenneth C Keiler

Funding

Molecular determinants of A-site mRNA cleavage ribosomeR01GM078634 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI HAYES, CHRISTOPHER S. · 2006 to 2014
$2.5M
The Role of tmRNA in development of C. crescentusR01GM068720 · NIGMS · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI KEILER, KENNETH C · 2004 to 2014
$2.3M
NIGMS NIH HHS GM068720NIGMS NIH HHS GM078634NIGMS NIH HHS R01 GM068720NIGMS NIH HHS R01 GM078634
6 · The paper itself

Abstract

tmRNA is a unique bi-functional RNA that acts as both a tRNA and an mRNA to enter stalled ribosomes and direct the addition of a peptide tag to the C terminus of nascent polypeptides. Despite a reasonably clear understanding of tmRNA activity, the reason for its absolute conservation throughout the eubacteria is unknown. Although tmRNA plays many physiological roles in different bacterial systems, recent studies suggest a general role for trans-translation in monitoring protein folding and perhaps other co-translational processes. This review will focus on these new hypotheses and the data that support them.

Indexed as

Protein BiosynthesisProtein FoldingBacteriaRibosomesRNA, BacterialRNA, BacterialtmRNA

Identifiers

PMID19914241
PMCPMC2794900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.