ArticleBiochimica et biophysica acta2010
Assessing the size, stability, and utility of isotropically tumbling bicelle systems for structural biology.
Article in Biochimica et biophysica acta, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Characterization of lipid solubilization, bicelle formation, and magnetic-alignment induced by saponins.Journal of colloid and interface science · 2026Article
- Dilute Bicelles for Glycosyltransferase Studies, Novel Bicelles with Phosphatidylinositol.The journal of physical chemistry. B · 2022Article
- Investigating the Disordered and Membrane-Active Peptide A-Cage-C Using Conformational Ensembles.Molecules (Basel, Switzerland) · 2021Article
- Formulation of Bicelles Based on Lecithin-Nonionic Surfactant Mixtures.Materials (Basel, Switzerland) · 2020Article
- Measuring Lipid Transfer Protein Activity Using Bicelle-Dilution Model Membranes.Analytical chemistry · 2020Article
- The Unusual Transmembrane Partition of the Hexameric Channel of the Hepatitis C Virus.Structure (London, England : 1993) · 2018Article
- Functional and structural evaluation of bovine heart cytochrome c oxidase incorporated into bicelles.Biochimie · 2016Article
- The magic of bicelles lights up membrane protein structure.Chemical reviews · 2012Review
- Bicelles at low concentrations.Molecular pharmaceutics · 2012Article
- Ice breaking in GPCR structural biology.Acta pharmacologica Sinica · 2012Review
- Reconstitution of integral membrane proteins into isotropic bicelles with improved sample stability and expanded lipid composition profile.Biochimica et biophysica acta · 2012Article
- Coupling efficiency of rhodopsin and transducin in bicelles.Biochemistry · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Aqueous phospholipid mixtures that form bilayered micelles (bicelles) have gained wide use by molecular biophysicists during the past 20 years for spectroscopic studies of membrane-bound peptides and structural refinement of soluble protein structures. Nonetheless, the utility of bicelle systems may be compromised by considerations of cost, chemical stability, and preservation of the bicelle aggregate organization under a broad range of temperature, concentration, pH, and ionic strength conditions. In the current work, (31)P nuclear magnetic resonance (NMR) and atomic force microscopy (AFM) have been used to monitor the size and morphology of isotropically tumbling small bicelles formed by mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) or 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine (DIOMPC) with either 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC) or 1,2-di-O-hexyl-sn-glycero-3-phosphocholine (DIOHPC), testing their tolerance of variations in commonly used experimental conditions. (1)H-(15)N 2D NMR has been used to demonstrate the usefulness of the robust DMPC-DIOHPC system for conformational studies of a fatty acid-binding protein that shuttles small ligands to and from biological membranes.
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Registered trials
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