ArticleNeuron2009
Extracellular Engrailed participates in the topographic guidance of retinal axons in vivo.
Article in Neuron, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.
- Of travelling homeoproteins and medulloblastomas.Oncogene · 2025Pooled it
- Long-range chemical signalling in vivo is regulated by mechanical signals.Nature materials · 2026Article
- Unravelling axonal transcriptional landscapes: insights from induced pluripotent stem cell-derived cortical neurons and implications for motor neuron degeneration.Open biology · 2025Article
- The Nuclear Transitory Zone: A Key Player in the Cerebellar Development.Cerebellum (London, England) · 2025Review
- Conserved roles of engrailed: patterning tissues and specifying cell types.Development (Cambridge, England) · 2024Review
- Therapeutic value of homeoprotein signaling pathways.Frontiers in neuroscience · 2024Review
- ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal α-motoneurons.EMBO reports · 2023Article
- A cationic motif upstream Engrailed2 homeodomain controls cell internalization through selective interaction with heparan sulfates.Nature communications · 2023Article
- Role of PI(4,5)P2 and Cholesterol in Unconventional Protein Secretion.Advances in experimental medicine and biology · 2023Article
- Unconventional Secretion, Gate to Homeoprotein Intercellular Transfer.Frontiers in cell and developmental biology · 2022Review
- Shuttling Homeoproteins and Their Biological Significance.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Non-cell-autonomous OTX2 transcription factor regulates anxiety-related behavior in the mouse.Molecular psychiatry · 2021Article
- Homeoprotein transduction in neurodevelopment and physiopathology.Science advances · 2020Review
- Global Analysis of Intercellular Homeodomain Protein Transfer.Cell reports · 2019Article
- Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain.eLife · 2019Article
- Primary sensory map formations reflect unique needs and molecular cues specific to each sensory system.F1000Research · 2019Review
- Axon-Seq Decodes the Motor Axon Transcriptome and Its Modulation in Response to ALS.Stem cell reports · 2018Article
- How to navigate counter dogmatic research findings.The EMBO journal · 2018Article
- AMolecular neurobiology · 2017Review
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
Engrailed transcription factors regulate the expression of guidance cues that pattern retinal axon terminals in the dorsal midbrain. They also act directly to guide axon growth in vitro. We show here that an extracellular En gradient exists in the tectum along the anterior-posterior axis. Neutralizing extracellular Engrailed in vivo with antibodies expressed in the tectum causes temporal axons to map aberrantly to the posterior tectum in chick and Xenopus. Furthermore, posterior membranes from wild-type tecta incubated with anti-Engrailed antibodies or posterior membranes from Engrailed-1 knockout mice exhibit diminished repulsive activity for temporal axons. Since EphrinAs play a major role in anterior-posterior mapping, we tested whether Engrailed cooperates with EphrinA5 in vitro. We find that Engrailed restores full repulsion to axons given subthreshold doses of EphrinA5. Collectively, our results indicate that extracellular Engrailed contributes to retinotectal mapping in vivo by modulating the sensitivity of growth cones to EphrinA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.