ArticleHeart rhythm2010
Mechanisms of sinoatrial node dysfunction in a canine model of pacing-induced atrial fibrillation.
Article in Heart rhythm, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Chronic amiodarone therapy impairs the function of the superior sinoatrial node in patients with atrial fibrillation.Circulation journal : official journal of the Japanese Circulation Society · 2013Trial
- Coffee Consumption Correlates With Better Cognitive Performance in Patients With a High Incidence for Stroke.Journal of the American Heart Association · 2025Observational
- Identification of miR-1 and miR-499 in chronic atrial fibrillation by bioinformatics analysis and experimental validation.Frontiers in cardiovascular medicine · 2024Article
- Three-dimensional electroanatomic mapping characteristics of superior vena cava myocardial sleeve and sinoatrial node in patients with atrial fibrillation.Frontiers in cardiovascular medicine · 2022Article
- Molecular Signatures of Sinus Node Dysfunction Induce Structural Remodeling in the Right Atrial Tissue.Molecules and cells · 2020Article
- Catheter Ablation is Effective for Recovery from Sinus Node Dysfunction in Patients with Atrial Fibrillation, But Close Monitoring is Still Needed.Korean circulation journal · 2020Article
- In silico study of the effects of anti-arrhythmic drug treatment on sinoatrial node function for patients with atrial fibrillation.Scientific reports · 2020Article
- TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome.The Journal of physiology · 2018Article
- The Absence of Atrial Contraction as a Predictor of Permanent Pacemaker Implantation after Maze Procedure with Cryoablation.The Korean journal of thoracic and cardiovascular surgery · 2017Article
- Function and dysfunction of human sinoatrial node.Korean circulation journal · 2015Review
- Atrial fibrillation complicated by heart failure induces distinct remodeling of calcium cycling proteins.PloS one · 2015Article
- Ca(2+) cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells.Frontiers in physiology · 2015Article
- Noninvasive imaging of sinus node disease: can it predict the need for pacemaker implantation?Journal of cardiovascular electrophysiology · 2012Article
- Abnormal response of superior sinoatrial node to sympathetic stimulation is a characteristic finding in patients with atrial fibrillation and symptomatic bradycardia.Circulation. Arrhythmia and electrophysiology · 2011Article
- The role of the calcium and the voltage clocks in sinoatrial node dysfunction.Yonsei medical journal · 2011Review
- Mapping cardiac pacemaker circuits: methodological puzzles of the sinoatrial node optical mapping.Circulation research · 2010Review
- Yin and yang of the cardiac pacemaker clock system in health and disease.Heart rhythm · 2010Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe mechanism of sinoatrial node (SAN) dysfunction in atrial fibrillation (AF) is unclear.
objectiveThe purpose of this study was to test the hypothesis that defective spontaneous sarcoplasmic reticulum (SR) Ca(2+) release (Ca(2+) clock) is in part responsible for SAN dysfunction in AF.
methodsArrhythmic events and SAN function were evaluated in pacing-induced AF dogs (n = 7) and in normal dogs (n = 19) with simultaneous intracellular calcium (Ca(i)) and membrane potential recording.
resultsAF dogs had frequent sinus pauses during Holter monitoring. Isolated right atrium (RA) from AF dogs showed slower heart rate (P = .001), longer SAN recovery time (P = .001), and longer sinoatrial conduction time (P = .003) than normal. In normal RAs, isoproterenol 0.3 and 1 mumol/L increased heart rate by 96% and 105%, respectively. In contrast, in RAs from AF dogs, isoproterenol increased heart rate by only 60% and 72%, respectively. Isoproterenol induced late diastolic Ca(i) elevation (LDCAE) at superior SAN in all 19 normal RAs but in only 3 of 7 AF RAs (P = .002). In AF RAs without LDCAE (n = 4), heart rate increased by the acceleration of ectopic foci. Caffeine (20 mmol/L) injection increased heart rate with LDCAE in all 6 normal RAs but did not result in LDCAE in any of the 5 AF RAs (P = .002). Type 2 ryanodine receptor (RyR2) in the superior SAN of AF dogs was decreased to 33% of normal (P = .02).
conclusionSAN dysfunction in AF is associated with Ca(2+) clock malfunction, characterized by unresponsiveness to isoproterenol and caffeine and down-regulation of RyR2 in SAN.
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