ArticleThe Journal of urology2010
Brain activity measured by functional magnetic resonance imaging is related to patient reported urgency urinary incontinence severity.
Article in The Journal of urology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Cognitive components of behavioral therapy for overactive bladder: a systematic review.International urogynecology journal · 2021Pooled it
- The placebo effect in overactive bladder syndrome.Nature reviews. Urology · 2011Pooled it
- Multicomponent Intervention for Overactive Bladder in Women: A Randomized Clinical Trial.JAMA network open · 2024Trial
- The Afferent Threshold Hypothesis: A Unified Neural Framework for Functional Bladder Capacity and Nocturia.International neurourology journal · 2026Article
- A novel behavioral paradigm for odor-induced voluntary urination in mice.Scientific reports · 2026Article
- Cerebellar functional connectivity relates to lower urinary tract function: A 7 Tesla study.Neurourology and urodynamics · 2024Article
- Functional brain imaging and central control of the bladder in health and disease.Frontiers in physiology · 2022Review
- Urinary dysfunction in patients with vascular cognitive impairment.Frontiers in aging neuroscience · 2022Review
- Testing a new, intensified infusion-withdrawal protocol for urinary urgency provocation in brain-bladder studies.Neurourology and urodynamics · 2021Article
- Ceftriaxone inhibits stress-induced bladder hyperalgesia and alters cerebral micturition and nociceptive circuits in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome research network study.Neurourology and urodynamics · 2020Article
- Urobiome: In Sickness and in Health.Microorganisms · 2019Review
- The Role of the Periaqueductal Gray Matter in Lower Urinary Tract Function.Molecular neurobiology · 2019Review
- Test-retest repeatability of patterns of brain activation provoked by bladder filling.Neurourology and urodynamics · 2017Article
- Female urinary microbiota.Current opinion in urology · 2017Review
- The Female Urinary Microbiota/Microbiome: Clinical and Research Implications.Rambam Maimonides medical journal · 2017Article
- Microbiota in 2016: Associating infection and incontinence with the female urinary microbiota.Nature reviews. Urology · 2017Review
- Urinary Microbiome and Psychological Factors in Women with Overactive Bladder.Frontiers in cellular and infection microbiology · 2017Article
- Article
- Urgency urinary incontinence and the interoceptive network: a functional magnetic resonance imaging study.American journal of obstetrics and gynecology · 2016Observational
- Health related quality of life (HRQOL) in long-term survivors of pediatric low grade gliomas (LGGs).Journal of neuro-oncology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe investigated the relationship between experimental neuroimaging and self-reported urinary incontinence measures. MATERIALS AND
methodsWe evaluated 14 functionally independent, community dwelling women older than 60 years with moderate to severe urgency urinary incontinence. All underwent detailed clinical assessment (3-day bladder diary, 24-hour pad test and quality of life assessment), urodynamic testing and functional brain scanning. Brain activity during reported urgency was assessed using a method that combines functional magnetic resonance imaging with simultaneous urodynamic monitoring during repeat bladder filling/emptying cycles. We used the statistical parametric mapping program SPM2 (http://www.fil.ion.ucl.ac.uk/spm/spm2.html) to correlate brain activity with relevant clinical covariates, including the number of urgency incontinent episodes, amount of urine leakage and psychological burden as assessed by the Urge Impact Scale questionnaire.
resultsActivity in rostral and subgenual anterior cingulate gyrus, insula, inferior frontal gyrus, orbitofrontal cortex, dorsal and posterior cingulate gyrus, parahippocampus, cuneus and parts of parietotemporal lobe correlated positively with daytime incontinence frequency and urine loss. Different brain regions correlated with the psychological burden and the associations were inverse, that is precuneus/cuneus and posterior cingulate gyrus, and superior temporal, supramarginal and transverse gyrus.
conclusionsAs provoked by bladder filling, regional brain activity in the setting of self-reported urgency correlates significantly with incontinence severity in daily life and the associated psychological burden. Thus, observations made under experimental conditions correlate with patient real-life experience and suggest neural correlates of urgency incontinence symptoms that could serve as potential targets for future investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.