Evidence map›Paper›PMID 19913626›Full record

ArticleNeuroImage2010

Impact of scanner hardware and imaging protocol on image quality and compartment volume precision in the ADNI cohort.

Frithjof Kruggel, Jessica Turner, L Tugan Muftuler, Alzheimer's Disease Neuroimaging Initiative

Abstract readMulticenter Study
In one paragraph

Article in NeuroImage, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it, 172 citations in OpenAlex.

  1. Accuracy of MRI-Based Radiomics in Diagnosis of Placenta Accreta Spectrum: A PRISMA Systematic Review and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Pooled it
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  17. A generalist model for enhancing brain MRIs.Nature biomedical engineering · 2025
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  20. BrainSuite BIDS App: Containerized Workflows for MRI Analysis.bioRxiv : the preprint server for biology · 2024
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Frithjof KruggelDepartment of Biomedical Engineering, University of California, Irvine, CA 92697-2755, USA. fkruggel@uci.edu
Jessica Turner
L Tugan Muftuler
Alzheimer's Disease Neuroimaging Initiative
University of California, Irvine · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
RECRUITMENT COREU19AG010483 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDMAN, HOWARD · 2013 to 2020
$80.6M
Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TED S ACOTT · 1995 to 2026
$19.4M
Translational Vision Science Research at Oregon Health & Science UniversityT32EY023211 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Yali Jia, Kate E Keller · 2013 to 2026
$2.4M
NEI NIH HHS P30 EY010572NEI NIH HHS T32 EY023211NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG010483
6 · The paper itself

Abstract

Morphometry of brain structures based on magnetic resonance imaging (MRI) data has become an important tool in neurobiology. Recent multicenter studies in neurodegenerative diseases raised the issue of the precision of volumetric measures, and their dependence on the scanner properties and imaging protocol. A large dataset consisting of 1073 MRI examinations in 843 subjects, acquired on 90 scanners at 58 sites, is analyzed here. A comprehensive set of image quality and content measures is used to describe the influence of the scanner hardware and imaging protocol on the variability of morphometric measures. Scanners equipped with array coils show a remarkable advantage over conventional coils in terms of image quality measures. The signal- and contrast-to-noise ratio in similar systems is equal or slightly better at 1.5 T than 3.0 T, while the white/grey matter tissue contrast is generally better on high-field systems. Repeated MRI investigations on the same scanner were available in 41 subjects, on different scanners in 172 subjects. The retest reliability of repeated volumetric measures under the same conditions was found as sufficient to track changes in longitudinal examinations in individual subjects. Using different acquisition conditions in the same subject, however, the variance of volumetric measures was up to 10 times greater. Two likely factors explaining this finding are scanner-dependent geometrical inaccuracies and differences in the white/grey matter tissue contrast.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedReproducibility of Results

Identifiers

PMID19913626
PMCPMC2951115
OpenAlexW2031224239

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.