ArticleHuman immunology2010
Alveolar macrophages in allergic asthma: an expression signature characterized by heat shock protein pathways.
Article in Human immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Meta-Analysis ofFrontiers in immunology · 2019Pooled it
- Multi-omics joint screening of biomarkers related to M2 macrophages in gastric cancer.Discover oncology · 2024Article
- The role of macrophage subtypes and exosomes in immunomodulation.Cellular & molecular biology letters · 2022Review
- Cross-Linking Cellular Prion Protein Induces Neuronal Type 2-Like Hypersensitivity.Frontiers in immunology · 2021Article
- Mechanisms Targeting the Unfolded Protein Response in Asthma.American journal of respiratory cell and molecular biology · 2021Review
- The Utility of Resolving Asthma Molecular Signatures Using Tissue-Specific Transcriptome Data.G3 (Bethesda, Md.) · 2020Article
- Role of Human Macrophage Polarization in Inflammation during Infectious Diseases.International journal of molecular sciences · 2018Review
- Functional macrophages and gastrointestinal disorders.World journal of gastroenterology · 2018Review
- ADGRE1 (EMR1, F4/80) Is a Rapidly-Evolving Gene Expressed in Mammalian Monocyte-Macrophages.Frontiers in immunology · 2018Article
- M1 and M2 Monocytes in Rheumatoid Arthritis: A Contribution of Imbalance of M1/M2 Monocytes to Osteoclastogenesis.Frontiers in immunology · 2017Article
- GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- In Utero exposure to genistein enhanced intranasal house dust mite allergen-induced respiratory sensitization in young adult B6C3F1 mice.Toxicology letters · 2016Article
- Sex differences in the acute in vivo effects of different human SP-A variants on the mouse alveolar macrophage proteome.Journal of proteomics · 2014Article
- The M1 and M2 paradigm of macrophage activation: time for reassessment.F1000prime reports · 2014Review
- Recognition of self-heat shock protein 60 by T cells from patients with atopic dermatitis.Cell stress & chaperones · 2013Article
- Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17.The Journal of allergy and clinical immunology · 2012Article
- Sex differences in the response of the alveolar macrophage proteome to treatment with exogenous surfactant protein-A.Proteome science · 2012Article
- In vivo rescue of alveolar macrophages from SP-A knockout mice with exogenous SP-A nearly restores a wild type intracellular proteome; actin involvement.Proteome science · 2011Article
- Expression analysis of asthma candidate genes during human and murine lung development.Respiratory research · 2011Article
- Alveolar macrophage gene expression is altered in the setting of alcohol use disorders.Alcoholism, clinical and experimental research · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The implication of alveolar macrophages (AM) in asthma, a T(h)2 disease, has not been well characterized. Thus, the goal of this study is to better characterize AM phenotype of allergic asthmatic compared with normal subjects using genomic expression analyses. Microarray analyses were performed with AM isolated from bronchoalveolar lavage. Robust multiarray analysis (RMA) normalization and Smyth's moderated t test were used to select differentially expressed genes. Fifty differentially expressed genes were identified. Nineteen have been classified in categories linked to stress or immune responses and among them; nine are part of the heat shock protein (HSP) family. Difference of expression for three (HSPD1, PRNP, SERPINH1) of the five selected genes were validated using real-time reverse transcription-polymerase chain reaction. Enzyme-linked immunosorbent assay was used to measure the protein level of heat shock protein 60 (HSP60), the protein encoded by HSPD1, and showed difference in AM protein level between allergic asthmatic and control subjects. In summary, this study suggests that HSP gene family, particularly HSP60, is involved in AM functions in a context of allergic asthma. These results also support the involvement of AM immune functions in the development of an allergic asthmatic response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.