ReviewFEBS letters2009
The molecular clockwork of a protein-based circadian oscillator.
Review in FEBS letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Taxonomic quasi-primes: peptides charting lineage-specific adaptations and disease-relevant loci.Protein science : a publication of the Protein Society · 2025Article
- Unraveling diversity by isolating peptide sequences specific to distinct taxonomic groups.bioRxiv : the preprint server for biology · 2025Article
- Spatio-temporal coherence of circadian clocks and temporal control of differentiation inmSystems · 2024Article
- Open Prebiotic Environments Drive Emergent Phenomena and Complex Behavior.Life (Basel, Switzerland) · 2019Review
- Recent evidence that TADs and chromatin loops are dynamic structures.Nucleus (Austin, Tex.) · 2018Review
- A thermodynamically consistent model of the post-translational Kai circadian clock.PLoS computational biology · 2017Article
- Article
- Identification of Light-Sensitive Phosphorylation Sites on PERIOD That Regulate the Pace of Circadian Rhythms in Drosophila.Molecular and cellular biology · 2015Article
- The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- The MAP kinase p38 is part of Drosophila melanogaster's circadian clock.PLoS genetics · 2014Article
- Article
- Robust circadian oscillations in growing cyanobacteria require transcriptional feedback.Science (New York, N.Y.) · 2013Article
- Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock.Biochemistry · 2013Article
- Revealing a two-loop transcriptional feedback mechanism in the cyanobacterial circadian clock.PLoS computational biology · 2013Article
- Intrinsic negative feedback governs activation surge in two-component regulatory systems.Molecular cell · 2012Article
- Quantifying the rhythm of KaiB-C interaction for in vitro cyanobacterial circadian clock.PloS one · 2012Article
- Sequence divergent RXLR effectors share a structural fold conserved across plant pathogenic oomycete species.PLoS pathogens · 2012Review
- Structures of Phytophthora RXLR effector proteins: a conserved but adaptable fold underpins functional diversity.The Journal of biological chemistry · 2011Article
- Temporal and spatial oscillations in bacteria.Nature reviews. Microbiology · 2011Review
- Understanding systems-level properties: timely stories from the study of clocks.Nature reviews. Genetics · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is governed by a core oscillator consisting of the proteins KaiA, KaiB, and KaiC. Remarkably, circadian oscillations in the phosphorylation state of KaiC can be reconstituted in a test tube by mixing the three Kai proteins and adenosine triphosphate. The in vitro oscillator provides a well-defined system in which experiments can be combined with mathematical analysis to understand the mechanism of a highly robust biological oscillator. In this Review, we summarize the biochemistry of the Kai proteins and examine models that have been proposed to explain how oscillations emerge from the properties of the oscillator's constituents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.