ArticleStructure (London, England : 1993)2009
Optically resolving individual microtubules in live axons.
Article in Structure (London, England : 1993), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Cystinosin regulates NaEMBO reports · 2026Article
- Cystinosin is involved in NabioRxiv : the preprint server for biology · 2025Article
- Intracellular transport dynamics revealed by single-particle tracking.Biophysics reports · 2021Article
- Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency.Autophagy · 2019Article
- The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration.Journal of leukocyte biology · 2019Article
- Cargos Rotate at Microtubule Intersections during Intracellular Trafficking.Biophysical journal · 2018Article
- Modeling the neuron as a nanocommunication system to identify spatiotemporal molecular events in neurodegenerative disease.International journal of nanomedicine · 2018Article
- The nano-architecture of the axonal cytoskeleton.Nature reviews. Neuroscience · 2017Review
- Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.The Journal of biological chemistry · 2017Article
- Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors.Nature nanotechnology · 2017Article
- TestSTORM: Versatile simulator software for multimodal super-resolution localization fluorescence microscopy.Scientific reports · 2017Article
- Drive the Car(go)s-New Modalities to Control Cargo Trafficking in Live Cells.Frontiers in molecular neuroscience · 2017Review
- Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.The Journal of biological chemistry · 2016Article
- Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses.Molecular biology of the cell · 2016Article
- Focusing super resolution on the cytoskeleton.F1000Research · 2016Review
- Compartmentalized Platforms for Neuro-Pharmacological Research.Current neuropharmacology · 2016Review
- Retrograde NGF axonal transport--motor coordination in the unidirectional motility regime.Biophysical journal · 2015Article
- A SxIP motif interaction at the microtubule plus end is important for processive retrograde axonal transport.Cellular and molecular life sciences : CMLS · 2014Article
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Authors and funding
3 authors.
Funding
Abstract
Microtubules are essential cytoskeletal tracks for cargo transportation in axons and also serve as the primary structural scaffold of neurons. Structural assembly, stability, and dynamics of axonal microtubules are of great interest for understanding neuronal functions and pathologies. However, microtubules are so densely packed in axons that their separations are well below the diffraction limit of light, which precludes using optical microscopy for live-cell studies. Here, we present a single-molecule imaging method capable of resolving individual microtubules in live axons. In our method, unlabeled microtubules are revealed by following individual axonal cargos that travel along them. We resolved more than six microtubules in a 1 microm diameter axon by real-time tracking of endosomes containing quantum dots. Our live-cell study also provided direct evidence that endosomes switch between microtubules while traveling along axons, which has been proposed to be the primary means for axonal cargos to effectively navigate through the crowded axoplasmic environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.